CAREER: Catalytic Methods in Functionalizing Single Bonds to Carbon

有了这一职业奖，化学合成计划将支持明尼苏达大学双子城分校的道格拉斯教授的研究，以研究与羰基相邻的碳西格马键的活化和功能化。首先，将开发新的方法，涉及酮、酯和醛中这些键的金属促进活化。一个主要的焦点将是将不饱和基团插入到活化键中。第二，将开展机械性工作，以加深对新反应性发展的理解。交叉和动力学同位素效应实验将告诉我们反应是如何进行的，并使我们深入了解改进的催化剂系统和不对称工艺的发展。最后，根据该奖项开发的方法将应用于一系列不同的合成挑战。应用范围从合成商品化学原料，如甲乙酮，到合成复杂的天然产品，如Dragmacidin E。道格拉斯教授还将发起两个将研究和教学交织在一起的教育项目。第一个项目涉及在大型化学课堂上进行基于发现的学习。有机化学入门课程的混合式、引导式探究和传统讲授教学计划将进行试点，并与适当的控制组进行测试。第二个项目是一个外展项目，涉及当地一所录音艺术高中，为主要代表人数不足的群体中的高危儿童提供服务。

With this CAREER Award, the Chemical Synthesis program is supporting the research of Professor Douglas of the University of Minnesota - Twin Cities for studies toward the activation and functionalization of carbon sigma bonds adjacent to carbonyls. First, new methods involving the metal-promoted activation of these bonds in ketones, esters, and aldehydes will be developed. A major focus will be on the insertion of unsaturated groups into the activated bonds. Second, mechanistic work will be undertaken to develop a deeper understanding of the new reactivity develop. Cross-over and kinetic isotope effect experiments will teach us how the reactions proceed and give insight in to the development of improved catalyst systems and asymmetric processes. Finally the methods developed under this award will be applied to a diverse set of synthesis challenges. Applications will range from the synthesis of commodity chemical feedstocks like methyl ethyl ketone to the synthesis of complex natural products like dragmacidin E.Professor Douglas will also initiate two educational projects that interweave research and teaching. The first project involves discovery-based learning in the large chemistry classroom. A hybrid, guided-inquiry and traditional-lecture teaching plan for introductory organic chemistry will be piloted and tested against appropriate control groups. The second program is an outreach program involving a local recording-arts high school that serves at-risk children from predominantly underrepresented groups.