Conference: 2nd BMES-SPRBM Conference on Cellular and Molecular Bioengineering, San Juan, Puerto Rico, January 3 - 7, 2012

本申请的目的是寻求美国国家科学基金会对第二届联合生物工程学会（BMES）和生物学和医学物理调节学会（SPRBM）细胞和分子生物工程会议（CMBE）（第30届SPRBM年度科学会议）（简称：第二届BMES-SPRBM CMBE会议）的支持。第一次以分子成像和机械转导为主题的联合会议（2011年）非常成功。本次联合会议（2012）将扩大范围，聚焦于细胞运动、基质、机械生物学和再生的主题。作为一门新兴的科学领域，细胞和分子生物工程使体外培养和改造细胞成为可能，并为细胞在再生中的作用提供了内在的见解。与此同时，对生命的细胞和分子基础的阐明成为20世纪最伟大的成就之一，最终导致了人类基因组的完整测序。今天，我们正处于一个惊人的融合之中，它为生物工程师创造了一个联系。BMES和sprbm都意识到这一重要联系的研究，现在，首届BMES- sprbmcbme联合会议是生物医学工程中有前途的子领域的新焦点的开始，也是这个令人兴奋的领域非常需要的论坛。智力优势：细胞运动、细胞/分子功能基质、机械生物学和再生的作用，如细胞外基质和体外和体内的操作，在细胞和分子水平上实现了新的基本再生，并提供了新的体内监测模式。因此，这些导致了BMES-SPRBM关于CMBE的首届联合会议的激动人心的主题。本申请将首先为提交的论文在科学价值的基础上被选中登上讲台的青年和初级研究人员、博士后和研究生提供支持，并促进少数民族和女性科学家在该领域的发展；二是促进宇宙微波背景宇宙宇宙这一令人兴奋的分支领域的出现和发展。摘要将发表在会议论文集上，并选择全文论文发表在《细胞与分子生物工程》的特刊上。本次会议的具体目的是：(1)描述细胞和分子运动性、基质、机械生物学和再生的现状，来自CMBE领域的领导者将概述细胞分子运动性、功能基质概念，回顾机械生物学和适应的现状，以及他们在分子/细胞/组织/功能和组织/器官再生方面的研究；(2)对CMBE的新兴领域进行头脑风暴，重点关注细胞/分子力学、运动性、功能矩阵和具有再生潜力的机械转导的作用，结果将发表在CMBE的特刊上；(3)为初级教师、研究人员和学生提供关于基金写作和机会的培训研讨会；(4)环境设置。会议计划将包括领奖台会议，邀请主题演讲者和其他受邀演讲者。我们也鼓励研究生、博士后和初级研究人员提交摘要。这些摘要将被组织成宣讲会议，并配有奶酪/葡萄酒招待会。组委会将选出9名研究生/博士后进行简短演讲，并选出6 - 8名初级研究人员参加青年和新星会议。广泛的影响：20世纪工程学的兴起给人类带来了深刻的变化。生物学的进步同样惊人。在体外培养和改造细胞成为可能，并为它们在再生中的作用提供了内在的见解。在现代生物学和生物工程中，细胞功能的机械调节作用一直是人们关注的焦点。细胞运动、细胞/分子功能基质以及机械生物学和再生的作用的爆发使细胞和分子水平上的新的基本再生成为可能，同时也为体内和患者提供了新的监测模式。

The objective of this application is to seek NSF support for the 2nd inaugural joint BiomedicalEngineering Society (BMES) and the Society for Physical Regulation in Biology and Medicine(SPRBM) Conference on Cellular and Molecular Bioengineering (CMBE) (30th SPRBM AnnualScientific Conference) (short: 2nd BMES-SPRBM Conference on CMBE). The first joint conference(2011) on the specific theme of Molecular Imaging and Mechanotransduction was extremelysuccessful. This joint CMBE conference (2012) will expand the scope and be focused the theme ofCell Motility, Matrix, Mechanobiology and Regeneration. As a rising science field the cellular andmolecular bioengineering became possible to culture and engineer cells outside the body, andprovide intrinsic insights for their role in regeneration. In the mean time, the elucidation of thecellular and molecular basis of life became one of the great achievements of the twentieth century,culminating in the complete sequencing of the human genome. Today we stand in the midst of anamazing convergence, which has created a nexus for bioengineers. Both the BMES and theSPRBM realized that research at this remarkable nexus, Now, the inaugural joint BMES-SPRBMConference on CBME is the beginning of a new focus of the promising subfield in biomedicalengineering and much needed forum for this exciting field.Intellectual merit: The explosions of cellular motility, cellular/molecular functional matrix and therole of mechanobiology and regeneration such as extracellular matrix and the manipulations in vitroand in vivo enables new fundamental regeneration at the cellular and molecular level, as well asproviding new monitoring modalities in vivo. Therefore, these lead to the exciting theme of theinaugural BMES-SPRBM joint Conference on CMBE. This application will be first is to providesupport to young and junior researchers, postdoctoral fellows, and graduate students whosesubmitted papers have been selected for podium presentation on the basis of scientific merits, andpromote minority and women scientists in the field; and second to foster the emergence and growthof the exciting sub-filed of CMBE. The abstracts will be published in a Conference Proceeding, andselected full length papers will be published in a special issue of Cellular and MolecularBioengineering.The specific aims of this meeting are: (1) delineate the current status of cellular and molecularmotility, matrix, mechanobiology and regeneration, in which leaders from the CMBE fields will givean overview of cellular molecular motility, functional matrix concepts and review the current state ofmechanobiology and adaptation, as well as their research in molecular/cellular/tissue/ functions andtissue/organ regeneration; (2) brainstorm the emerging field of CMBE with a focus on the role ofcellular/molecular mechanics, motility, functional matrix and mechanotransduction with regenerationpotentials, which the outcome will be published in a special issue of CMBE; (3) provide trainingworkshop for junior faculty, investigators, and students on grant writing and opportunities; and (4)environment setting. The conference program will include Podium Sessions with invited Keynotespeakers and other invited speakers. Graduate students, postdoctoral fellows, and juniorinvestigators will also be encouraged to submit abstracts. These abstracts will be organized into aposter session with cheese/wine receptions. Nine graduate students/postdoctoral fellows will beselected by the organizing committee to present short talks and six-eight junior investigators will beselected for a Young and Rising Star session.Broad impacts: The rise of engineering in the twentieth century led to profound change forhumankind. The advances in biology are equally amazing. It became possible to culture andengineer cells outside the body, and provide intrinsic insights for their role in regeneration. The roleof mechanical modulation of cell functions has been an intensive focus in modern biology andbioengineering. The explosions of cellular motility, cellular/molecular functional matrix and the roleof mechanobiology and regeneration enables new fundamental regeneration at the cellular andmolecular level, as well as providing new monitoring modalities in vivo and in patients.