Role of Histone deacetylase 3 (HDAC3) in intestinal epithelial cell homeostasis and tumorigenesis

结肠癌是影响澳大利亚男性和女性的最常见癌症。每年，仅在维多利亚，就有3400多人被诊断出患有结肠癌。随着时间的推移，结肠癌是通过关键基因突变的积累而产生的。致癌基因的鉴定为设计新的癌症疗法提供了基础。我们最近发现了一种名为组蛋白去乙酰化酶3（HDAC3）的基因，它可能与促进结肠癌有关。目前的提议将在小鼠中扩展和验证这一发现。重要的是，抑制HDAC 3的药物最近已被开发用于治疗皮肤T细胞淋巴瘤。确定HDAC3在结肠癌中的作用将证明在结肠癌患者中测试这些药物是合理的。

Colon cancer is the most common cancer that affects men and women in Australia. Annually, in Victoria alone, more than 3400 people are diagnosed with colon cancer. Colon cancer arises through the accumulation of mutations in key genes over time. Identification of cancer causing genes provides the basis for the design of new cancer therapies. We recently identified a gene called Histone deacetylase 3 (HDAC3) as potentially involved in promoting colon cancer. The current proposal will now extend and validate this finding in mice. Importantly, drugs which inhibit HDAC3 have recently been developed for the treatment of cutaneous T-cell lymphoma. Defining the role HDAC3 plays in colon cancer will justify testing these drugs in colon cancer patients.