EAGER: Red Blood Cell Membrane Camouflaged Nanoparticles for Drug Delivery

ID：MPS/DMR/BMAT（7623）1216461 主要研究者：张良芳 ORG：UC San Diego标题：EAGER：红细胞膜隐形纳米颗粒药物输送智力优势：该奖项的研究目标是研究一种创新的仿生纳米颗粒平台，该平台使用天然红细胞（RBC）膜，而不是传统的合成隐形生物材料，以掩盖合成纳米颗粒用于药物输送。 所采取的方法将是利用一种新的和革命性的自上而下的策略，通过将RBC的整个细胞“效用涂层”转移到药物纳米载体的表面上来使纳米颗粒功能化。 预期如此修饰的纳米颗粒表现出与其源细胞相似的生理行为。 为了实现这一主要目标，本项目将开展两项具体的研究任务：（i）研究红细胞膜包覆的聚合物纳米颗粒的物理化学和生物学性质;（ii）探索将靶向配体引入红细胞膜包覆的纳米颗粒表面以实现靶向药物递送的有效方法。如果成功，该项目将开发一种全新的仿生纳米颗粒，将RBC膜与合成生物材料结合起来。 这种天然细胞成分与合成生物材料的组合为开发新型和强大的药物递送纳米载体提供了一种创新方法，并将对生物材料研究和纳米技术药物递送领域产生深远的影响。 此外，这项工作高度融合了研究和教育。 在本项目期间，将开展两项教育工作：（一）PI将开设新课程，以塑造和影响无标题州“纳米工程”第一个本科课程的发展。 该课程将作为其他机构开发类似项目的典范。 (ii)PI将与加州大学圣地亚哥分校ET-CURE项目合作，为少数族裔本科生提供激动人心的研究体验。 PI将招募1-2名少数民族大学生参与该项目。

ID: MPS/DMR/BMAT(7623) 1216461 PI: Zhang, Liangfang ORG: UC San DiegoTitle: EAGER: Red Blood Cell Membrane Camouflaged Nanoparticles for Drug DeliveryINTELLECTUAL MERIT: The research objective of this award is to study an innovative biomimetic nanoparticle platform that uses natural red blood cell (RBC) membranes, rather than conventional synthetic stealth biomaterials, to cloak synthetic nanoparticles for drug delivery. The approach taken will be to utilize a novel and revolutionary top-down strategy to functionalize nanoparticles by transferring the entire cellular 'utility coat' of an RBC onto the surface of drug nanocarriers. A nanoparticle thus modified is expected to exhibit similar physiologic behavior as its source cells. To achieve the primary goal, two specific research tasks will be pursued in the proposed project: (i) study the physicochemical and biological properties the RBC membrane cloaked polymeric nanoparticles, and (ii) explore effective approaches to incorporate targeting ligands on the surface of the RBC membrane cloaked nanoparticles for targeted drug delivery.BROADER IMPACTS: If successful, this project will develop an entirely new class of biomimetic nanoparticles that combines RBC membranes with synthetic biomaterials. Such a combination of natural cellular components with synthetic biomaterials presents an innovative approach to develop novel and powerful drug delivery nanocarriers and will have profound impacts on the fields of biomaterials research and nanotechnology drug delivery. Moreover, this work highly integrates research and education. Two education thrusts will be carried out during the period of this project: (i) The PI will create new courses to shape and impact the development of the first undergraduate curriculum in 'nanoengineering' in the Untitled States. This curriculum will be provided as a model for the development of similar programs at other institutions. (ii) The PI will collaborate with the UCSD ET-CURE Program to provide minority undergraduate students with stimulating research experiences. The PI will recruit 1-2 minority undergraduate students to work on this project.