2012 Biocatalysis Gordon Research Conference (GRC) / July 8-13, 2012, Bryant University - Smithfield, RI

1219595 LutzBiocatalysis包括使用分离的酶或全细胞系统将容易获得的廉价起始材料转化为高价值产品。 酶是完全可回收的催化蛋白质，其经常显示出精致的化学选择性、对映体选择性和区域选择性，并且在温和的pH和温度条件下操作。 这些特性使酶成为具有成本效益和可持续性的催化剂，用于广泛的化学转化。 蛋白质发现、设计和工程的现代工具有助于开发新型生物催化剂，并将其定制设计整合到工业过程中。 因此，生物催化剂可应用于医药中间体、新型材料和诊断试剂以及精细、高性能和农用化学品的生产。该提案要求支持第十二届两年一度的戈登生物催化研究会议（GRC）。 会议将于2012年7月8日至13日在罗得岛史密斯菲尔德的布莱恩特大学举行。 会议之前将于2012年7月7日至8日举行第一次相关研究生研究研讨会（GRS）。 这些会议将汇集研究生，博士后研究员和该领域的领导者，讨论从研究工作台到工业生产工厂的生物催化的最新科学和技术进展。主题包括：- 生物催化中的合成生物学-生物催化剂的设计和工程-级联反应系统-过程的设计和工程-生物催化中的学术和工业趋势-合成中的生物催化-工业生物催化-绿色化学的未来挑战为了更好地促进研究生和博士后之间的科学交流，GRC的联合主席已经建立了一个研究研讨会，年轻的科学家将展示他们的研究成果，并讨论他们的工作对未来的潜在影响。 早期职业研究人员的参与将为本次会议增添重要价值，并将促进该领域当前和未来领导者之间的沟通。 小，高度互动的设置有助于促进知识的话语，网络和合作。

1219595LutzBiocatalysis encompasses the use of isolated enzymes or whole cell systems for conversion of readily available, inexpensive starting materials to high-value products. Enzymes are fully recyclable catalytic proteins that frequently display exquisite chemo-, enantio- and regioselectivity and operate under mild conditions of pH and temperature. These characteristics make enzymes cost effective and sustainable catalysts for a wide range of chemical transformations. Modern tools of protein discovery, design and engineering aid the development of novel biocatalysts and their tailor-designed integration into industrial processes. Consequently, biocatalysts have applications to the production of pharmaceutical intermediates, novel materials and diagnostics, as well as fine, performance and agro-chemicals.The proposal requests support for the twelfth biennial Gordon Research Conference (GRC) on Biocatalysis. The conference will take place at Bryant University, in Smithfield, Rhode Island on July 8-13, 2012. The meeting will be preceded by the first associated Graduate Research Seminar (GRS) on July 7-8, 2012. Together, these meetings will bring together graduate students, postdoctoral fellows, and leaders of the field to discuss the latest scientific and technological advances in biocatalysis from the research bench to the industrial production plant. Topics include: - synthetic biology in biocatalysis- design and engineering of biocatalysts- cascade reaction systems- design and engineering of processes- academic and industrial trends in biocatalysis- biocatalysis in synthesis- industrial biocatalysis- future challenges in green chemistry In an effort to better facilitate scientific exchange between graduate students and postdoctoral fellows, the co-chairs of the GRC have established a research seminar where the young scientists will present their research findings and discuss potential future implications of their work. Participation by early career researchers will add significant value to this conference and will foster communications among current and future leaders in the field. The small, highly interactive setting helps foster intellectual discourse, networking, and collaborations.