MRI: Acquisition of a Biplane Fluoroscopy System for Dynamic Imaging of In-Vivo Human Motion

提案#：12-29148PI(S)：Rullkoetter，Paul；Davidson，Bradley；Fitzpatrick，Clare；Laz，Peter J；Shelburne，Kevin研究所：丹佛大学标题：核磁共振/Acq.：用于活体人体运动动态成像的双平面透视系统项目提议：该项目获得一种称为双平面(2D)透视系统的仪器，旨在准确地测量运动学。该仪器是目前商业上最先进的记录人体骨骼运动的技术，利用专门的软件可以将测量数据转换为高精度和高分辨率的图像。与该机构现有的计算研究能力合作，双平面(2D)未来透视系统将主要用于人体动力学实验室，从而刺激国内机构以及其他五个合作机构和三个临床中心在生物力学研究方面的重要扩展。预计该系统将对生物力学研究产生变革，既是以前未报道的关节运动学的直接测量工具，也是最先进的计算模型的输入。此外，由此产生的研究还有望在实验和建模能力(全身运动、肌电和力测量以及肌肉骨骼、有限元和概率建模)的组合方面进行全面的研究。使用该仪器准确测量运动学应该有助于在骨科和植入物设计、辅助技术、理解损伤机制、康复和人体运动的运动控制方面取得科学进步。广泛的影响：该仪器可以极大地影响改善患者预后的能力。考虑到拟议工作的临床性质，新的生物力学设计和发现可以转化为改善那些遭受健康伤害的人的生活质量。它还有助于为该机构、合作伙伴大学和落基山西部地区建立一个特殊的研究和教育环境。获得的系统将为STEM推广项目的学生，包括本科生和研究生，以及医学生和临床住院医生提供积极的学习和研究体验。

Proposal #: 12-29148PI(s): Rullkoetter, Paul; Davidson, Bradley; Fitzpatrick, Clare; Laz, Peter J; Shelburne, KevinInstitution: University of DenverTitle: MRI/Acq.: A Biplane Fluoroscopy System for Dynamic Imaging of In-Vivo Human MotionProject Proposed:This project, acquiring an instrument referred to as Biplanar (2D) Fluoroscopy System, aims to accurately measure kinematics. The instrument, currently the most advanced commercially available technology to record human skeletal motion, utilizes specialized software that can translate the measured data into images of high accuracy and resolution. In collaboration with existing computational research capabilities at the institution, the Biplanar (2D) Fuoroscopy System will be mainly used in the Human Dynamics Laboratory, thus stimulating an important expansion in biomechanics research at the home institution, along with the five other collaborating institutions and three clinical centers. The system is expected to be transformative to biomechanics research, both as a direct measurement instrument of previously unreported joint kinematics and as input to state-of-the-art computational models. Moreover, the resulting research is also expected to be comprehensive in the combination of experimental and modeling capabilities (whole-body motion, electromyography and force measurements and musculoskeletal, finite element, and probabilistic modeling). Accurate measurement of kinematics using the instrument should contribute to create scientific advancements in orthopedics and implant design, assistive technologies, understanding injury mechanisms, rehabilitation, and motor control of human movement.Broader Impacts: The instrument can greatly impact the capability to improve patient outcomes. Given the clinical nature of the proposed work, new biomechanical designs and discoveries could translate into improving the quality of life for those suffering from health injuries. It also contribute to build an exceptional research and education environment for the institution, partner universities and the Rocky Mountain West. The acquired system will provide active learning and research experiences for students in STEM outreach programs, both undergraduate and graduate students, as well as medical students and clinical residents.