Workshop: International Meeting on Protein Folding and Dynamics; to be held October 15-17, 2012 in Bangalore, India

该奖项是为了支持将于2012年10月15-17日在印度班加罗尔国际生物科学中心(NCB)举行的为期两天的“蛋白质折叠和动力学国际会议”。会议的目的是将来自美国、欧洲和亚洲的科学家聚集在一起，讨论蛋白质折叠领域的最新进展和未来研究。此外，该会议还将作为一个首届论坛，将新发起的机构(NCB、慕尼黑工业大学和马里兰大学)的一些活动介绍到生命系统物理(POLS)网络中。因此，这次会议承担着向国家协调机构的学生正式告知Pols网络的活动和好处的重要性。在被邀请的发言者中，有几位也是网络节点的一部分。大约20名代表广泛专业知识和远见的研究人员将聚集在一起，目的是评估蛋白质折叠中的突出问题，以及这些问题与更大规模的功能之间的关系。这次研讨会将召集大约20名发言者，他们代表蛋白质折叠的所有领域，以及与蛋白质组装成更大的复合体和更高层次的有序结构有关的领域。生物学中最大的挑战之一是将个体亚单位水平上的知识和能力与描述这些相互作用如何影响细胞水平上的功能的能力结合起来。会议的主要目的是确定未来十年必须在理论、模拟和实验中解决的主要问题，以便能够评估和预测蛋白质在细胞水平上协同和单独执行多种功能所起的作用。会议将涵盖蛋白质折叠领域中尚未解决的主要问题，确定共同的主题，并为如何整合单个亚基的行为来描述系统层面的现象绘制一条路线。更广泛的影响：这个研讨会是一种独特的方式，让世界上一些顶尖的科学家聚集在一起，讨论在传统会议上从未如此深入讨论的话题。其次，在确定新的研究领域方面，思想交流将是至关重要的，这些领域必须在不久的将来得到解决，因为我们正在为下一阶段的生物学定量研究制定语言和框架。具有物理、化学和生物学背景的广泛范围的科学家将聚集在一起，以确定必须解决的问题和确定需要采取的方法。

This award is in support of a two-day meeting entitled "International Meeting on Protein Folding and Dynamics" to be held at the International Center for Biological Sciences (NCBS) in Bangalore, India, on October 15-17, 2012. The purpose of the meeting is to bring together scientists from the USA, Europe, and Asia to discuss recent advances and future research in the area of protein folding. In addition, the conference will serve as an inaugural forum for introducing some of the activities in the newly initiated institutions (NCBS, Technical University of Munich, and the University of Maryland) into the Physics of Living Systems (POLS) network. This conference, therefore, takes on the importance of formally informing the students in NCBS to the activities and benefits of the POLS network. Among the invited speakers several are also part of the Network nodes.About twenty researchers representing a broad range of expertise and vision will be assembled with the purpose of assessing the outstanding problems in folding of proteins, and how these are related to function at larger scales. This workshop will convene about 20 speakers that represent all areas of protein folding as well as areas related to the assembly of proteins into larger complexes and higher order organized structures. One of the great challenges in biology is to integrate knowledge and capabilities at the individual subunit level with the ability to describe how these interact to affect function at the cellular level. The major aim of the meeting is to identify major issues that must be addressed in theory, simulations, and experiments in the next decade so that the roles which proteins play to carry out the myriad functions at the cellular level, in concert and in isolation, can be assessed and predicted. The meeting will cover the major unsolved problems in the area of protein folding, identify common themes, and chart a course for how to integrate the behavior of individual subunits to describe phenomena at the systems level. Broader impacts: This workshop is a unique way to assemble some of the leading scientists in the world to discuss topics that are never discussed in such depth at traditional meetings. Second, the exchange of ideas will be crucial in identifying new areas of research, which have to be tackled in the immediate future as we develop a language and framework for the next phase of quantitative research in biology. A broad spectrum of scientists with backgrounds in physics, chemistry and biology will be brought together to define the issues that have to be tackled and to identify the approaches that are needed.