Conference: 2012 Intrinsically Disordered Proteins GRC; to be held July 8-13, 2012 in West Dover, VT

这是第二次戈登内在无序蛋白（IDPs）研究会议，将于2012年7月8日至7月13日举行。生物功能是基于分子识别的，复杂的网络是围绕一系列相互关联的蛋白质-蛋白质和蛋白质-核酸界面组织起来的。传统观点认为，分子识别是通过蛋白质与其结合伙伴之间的形状互补和特定相互作用的结合来实现的。然而，传统观点正受到观察的挑战，大约30%的真核蛋白质不能自主折叠，而它们的无法折叠是功能所必需的。这类蛋白质，被称为内在无序蛋白质或IDPs，涉及多种功能，包括生物学中的基本过程。IDPs为分子识别增加了一个新的维度，因为它们经历了大规模的构象变化，并且它们提出了一个问题，即尽管缺乏精确的预组织形状互补，但如何实现识别的特异性。这是将IDP领域的科学家聚集在一起确定重要问题，评估当前进展，并为在构象异质性及其在蛋白质功能中的作用的研究中取得快速和有意义的进展制定路线的好时机。戈登内在无序蛋白质会议的特点是一群杰出的、多样化的科学家站在IDP领域的研究前沿。会议围绕转录调控、信号通路和模块、境内流离失所者阶段行为和分子识别、研究境内流离失所者的新兴技术、境内流离失所者质量控制和动态平衡、境内流离失所者的调节自组装和错组装，以及境内流离失所者的定位、贩运和处理等主题会议组织。研究国内流离失所者需要新的技术进步，因此会议将展示最先进的生物物理方法的发展，理论和计算的进步，以及与分子生物学新工具的协同作用，以研究国内流离失所者并对其体内功能进行定量理解。更广泛的影响戈登研究会议将促进对国内流离失所者在不同层次和不同领域的研究。会议高度重视了解国内流离失所者发挥作用的机制和发展新的综合方法，以研究和描述国内流离失所者的形式和功能。在最后一个项目中，40位受邀演讲者和讨论领袖中有12位是女性。这个项目既有成熟的科学家，也有年轻的科学家。在为博士后演讲者预留的两个项目名额中，会议主席将努力至少填补一个席位，由女性或少数族裔成员担任。会议主席还将确保在选择会议参与者阶段，选择少数民族参与者参加会议。在从申请人中挑选与会者时，除了申请日期和申请人的科学背景外，还将以少数群体、妇女和初级科学家方面的平权行动原则作为标准。

Intellectual Merit This is the second the Gordon Research Conference on Intrinsically Disordered Proteins (IDPs) to be held between July 08 and July 13, 2012. Biological functions are based on molecular recognition and complex networks are organized around a series of inter-related protein-protein and protein-nucleic acid interfaces. The traditional view posits that molecular recognition is achieved through a combination of shape complementarity and specific interactions between a protein and its binding partner. Traditional views are, however, being challenged by observations that roughly 30% of eukaryotic proteins fail to fold autonomously and their inability to fold is required for function. Such proteins, referred to as intrinsically disordered proteins or IDPs are implicated in a wide variety of functions that include fundamental processes in biology. IDPs add a new dimension to molecular recognition because they undergo large-scale conformational changes and they raise the question of how specificity in recognition is achieved despite the absence of precise pre-organized shape complementarity. This an opportune time to bring together scientists in the IDP field to identify the important questions, take stock of current progress, and chart the course for rapid and meaningful progress in the study of conformational heterogeneity and its role in protein function. The Gordon Conference on Intrinsically Disordered Proteins features an outstanding and diverse group of scientists at the forefront of research in the IDP field. The conference is organized around thematic sessions focusing on transcriptional regulation, signaling pathways and modules, IDP phase behavior and molecular recognition, emerging technologies for studying IDPs, IDP quality control and homeostasis, regulated self-assembly and mis-assembly of IDPs, and IDP targeting, trafficking and processing. Novel technological advances are needed to study IDPs therefore the conference will showcase the development of state-of-the art biophysical methods, advances in theory and computation, and the synergy with novel tools from molecular biology, for studying IDPs and developing a quantitative understanding regarding their functions in vivo. Broader ImpactThis Gordon Research Conference will promote research of IDPs at different levels and in various fields. The meeting has a highly relevant and synergistic focus on understanding the mechanisms by which IDPs function and the development of new integrated methods for studying and characterizing IDP form and function. In the final program, 12 of the 40 invited speakers and discussion leaders are women. The program has a balanced mixture of established and young scientists. Of the two program slots set aside for postdoctoral speakers, the conference chairs will strive to fill at least one with a woman / member of an under-represented minority community. The conference chairs will also ensure that at the stage of selection of participants in the meeting, minority participants will be selected to attend the meeting. When the attendees are selected from the pool of applicants, principles of affirmative action with respect to minority groups, women and junior scientists will be used as criteria, in addition to the date of application and the scientific background of the applicant.