CAREER: SusChEM - Sustainable Palladium-Catalyzed C-C Bond-Forming Reactions

化学合成项目正在为印第安纳大学的Silas Cook教授的研究提供这一职业奖。库克教授的实验室致力于设计可能导致碳-碳键形成的新方法的反应歧管。通过在迁移插入路径中利用烷基亲电分子生成的Csp3-碳钯中间体，可以避免一般的β-氢化物消除问题。一旦避免了β-氢化物的消除，复杂的级联反应将被开发出来，这将简化复杂分子结构的合成。具体地说，将探索基于烷基钯键中的炔基插入的反应。这种方法应该消除了标准的钯介导的交叉偶联反应所需的预官能化，从而减少了浪费并提高了这些合成转化的可持续性。这一研究计划的成功开发预计将对需要制备合成有机化合物的广泛努力产生积极影响，包括制药、农用化学品和材料工业，以及生物和化学研究。职业奖还将为两个教育项目提供支持。第一个项目允许印第安纳大学的本科生将他们的研究经验带回印第安纳州农村的家乡，与以前的高中老师合作教授催化课程。这些本科生催化大使将使用动手演示，并讨论他们正在进行的研究，以招募下一代科学家。第二个项目旨在改进和扩展团队在iPhone、iPod和iPad上的iOS“命名反应”应用程序。这个免费的教育软件有可能接触到世界各地的初出茅庐的科学家。

The Chemistry Synthesis program is supporting the research of Professor Silas Cook at Indiana University with this CAREER award. Professor Cook's laboratory works to design reaction manifolds that may lead to new approaches in carbon-carbon bond formation. By utilizing Csp3-carbopalladium intermediates generated from alkyl electrophiles in migratory insertion pathways, the general problem of beta-hydride elimination can be avoided. Once beta-hydride elimination is avoided, complexity building cascade reactions will be developed, which would streamline the synthesis of complex molecular architectures. Specifically, reactions based on the alkyne insertions into alkylpalladium bonds will be explored. This approach should eliminate the pre-functionalization required for standard palladium-mediated cross-coupling reactions, thereby reducing waste and improving the sustainability of these synthetic transformations. The successful development of this research program is expected to have positive impact on a wide range of endeavors requiring the preparation of synthetic organic compounds, including pharmaceutical, agrochemical, and materials industries, as well as biological and chemical research. The CAREER Award will also provide support for two education programs. The first program allows Indiana University undergraduate students to take their research experience back to their hometowns in rural Indiana to team-teach classes on catalysis with their former high school teachers. These undergraduate Ambassadors of Catalysis will use a hands-on demonstrations and discuss their ongoing research to recruit the next generation of scientists. The second program seeks to improve and expand the team's iOS 'Named Reactions' application for the iPhone, iPod, and iPad. This free educational software has the potential to reach budding scientists throughout the world.