SEES Fellows: Recyclable Solid Supports as a Sustainable Platform Technology

在NSF科学、工程和教育促进可持续发展研究员(SEE FERLOS计划)颁发的这一奖项中，来自麻省理工学院的Frank Leibfarth博士将开发可回收固体载体，用于高效、经济地生产复杂分子，包括多糖、多肽和寡核苷酸。该奖项得到了工程学理事会以及数学和物理科学理事会中的化学部和材料科学部的支持。拟议的工作将把聚合物载体上的固相合成与动态共价化学与连续流动系统相结合，以进行产生目标分子的反应。这项工作中提出的研究的目的是开发更好、更有效的方法来合成复杂分子(例如药物)，并最大限度地减少化学废物的产生。莱布法斯将与麻省理工学院化学系的Timothy F.Jamison教授和诺华生物医学研究所的Sejal Patel博士合作。莱布法斯博士还将与麻省理工学院工程外展办公室以及西班牙裔专业工程师协会合作开展教育项目。该项目由NSF科学、工程和教育促进可持续发展研究员(SEE FERLOS)计划支持，目标是帮助实现必要的发现，为导致环境、能源和社会可持续发展的行动提供信息，同时培养必要的劳动力来应对这些挑战。在SEES研究员的支持下，该项目将使有前途的早期职业研究人员能够在与可持续发展相关的独立研究生涯中站稳脚跟。

In this Award from the NSF Science, Engineering and Education for Sustainability Fellows (SEES Fellows Program) Dr. Frank Leibfarth from the Massachusetts Institute of Technology will develop recyclable solid supports for the efficient and economical production of complex molecules, including polysaccharides, peptides and oligonucleotides. This award has support from: the Directorate for Engineering; and the Division of Chemistry and the Division of Materials Science in the Directorate for Mathematical and Physical Sciences.The proposed work will combine solid phase synthesis on a polymer support with dynamic covalent chemistry with a continuous flow system to carry out the reactions that create the target molecules. The aim of studies like that proposed in this work is to develop better, more efficient methods for the synthesis of complex molecules (e.g. pharmaceuticals) with minimum production of chemical waste.Dr. Leibfarth will be working with collaborators Prof. Timothy F. Jamison of the Department of Chemistry at the Massachusetts Institute of and Dr. Sejal Patel of Novartis Institutes of Biomedical Research. Dr. Leibfarth will also work with the MIT Office of Engineering Outreach as well as the Society of Hispanic Professional Engineers on educational projects. This project is supported under the NSF Science, Engineering and Education for Sustainability Fellows (SEES Fellows) program, with the goal of helping to enable discoveries needed to inform actions that lead to environmental, energy and societal sustainability while creating the necessary workforce to address these challenges. With SEES Fellows support, this project will enable a promising early career researcher to establish themselves in an independent research career related to sustainability.