MRI: Acquisition of PS-3 Automated Peptide Synthesizer to Enhance Research and Training at Texas A&M International University

1335988 GuptaMRI项目建议书要求为PS3多肽自动合成器系统提供资金，以促进德克萨斯州南部的拉美裔服务机构德克萨斯农工大学(TAMIU)多肽化学实验室的扩建。为了促进TAMU研究的持续扩展和更好地为学生提供教育/研究机会，本提案要求为下列设备提供资金：1)有助于对细胞穿透肽(CPPs)转运细胞膜的机制的有限了解；2)增加对哪些关键蜘蛛丝肽与特定机械特性有关的知识；3)阐明碳水化合物受体导致癌细胞恶性行为的机制；4)为大量主要是西班牙裔学生提供培训并获得研究方法，他们在数学和科学专业中的代表性历来较低；5)增加现有几门生物学课程的教育经验，并能够开设一门额外的关于聚合物的选修化学课程；6)促进校内外合作，7)提高S在校外研究经费和出版物方面的竞争力。

1335988GuptaThis MRI project proposal requests funds for an automated PS3 peptide synthesizer system tofacilitate the expansion of a peptide chemistry laboratory at Texas A&M International University(TAMIU), a Hispanic serving institution in South Texas. To foster the continued expansionof research at TAMIU and to better provide educational/research opportunities for their students,this proposal requests funding for equipment that will: 1) contribute to the limited understandingof the mechanism by which cell penetrating peptides (CPPs) translocate cell membranes; 2)increase knowledge of which key spider silk peptides are associated with specific mechanicalproperties; 3) elucidate the mechanisms of carbohydrates receptors responsible for malignantbehavior of cancerous cells 4) provide training and access a research methodology to a largenumber of predominantly Hispanic students, who are historically underrepresented in math andscience professions; 5) augment the education experience of several existing biology coursesand enable the creation of an additional elective chemistry course on polymers; 6) fosterintramural and extramural collaborations, and 7) increase TAMIU?s competitiveness for extramuralresearch funding and publications.