SBIR Phase I: A green enzyme-based oxidative platform for fine chemical synthesis and remediation applications

这个小型企业创新研究第一阶段项目旨在提高高潜力氧化酶在化学合成和化学修复应用中的有效性。基于酶的系统是迄今为止已知的最绿色和最节能的过程，由于其在节能和环境效益方面的卓越潜力，正在取代基于化学的系统。然而，虽然处于绿色化学革命的前沿，但基于酶的系统很难获得。它们的采用没有那么快，没有那么广泛，也没有像其他方式那样有益，因为氧化酶的成本效益不足以取代化学物质。该项目正在开发一种用于工业用途的氧化酶的综合技术。项目目标包括(1)制造用于加工ZYMtronix？S催化剂的连续流动反应器，(2)开发用于癌症治疗的关键药物前体的合成工艺，(3)展示工业污染物的修复应用。该项目更广泛的商业潜力是促进氧化酶在合成和修复应用中的采用，因为它们可以取代贵金属催化剂、有毒溶剂和能源密集型过程。额外的好处转化为制造商、消费者和环境更安全的工艺和产品。ZYMtronix正在申请专利的技术与化学体系相比，在提高酶活性、减少酶抑制并扩大酶的可操作条件范围方面，估计大大提高了操作效率和成本效益。与正在开发的专利反应堆相结合，这些催化剂可以回收用于连续使用。ZYMtronix的S技术服务于适用于氧化酶工艺的精细化工、制药以及水处理市场。

This Small Business Innovation Research Phase I project aims to increase the effectiveness of oxidative enzymes of high potential in chemical synthesis and chemical remediation applications. Enzyme-based systems, the greenest and most energy efficient processes known to-date, are replacing chemical-based systems due to their superior potential for energy savings and environmental benefits. While at the forefront of the green chemistry revolution, however, enzyme-based systems are difficult to come by. Their adoption has not been as fast, as widespread, or as beneficial as it otherwise could be because oxidative enzymes are not cost effective enough to replace chemicals. This project is developing an integrated technology for oxidative enzymes for industrial use. The project objectives consist of (1) manufacturing continuous flow reactors dedicated to processing ZYMtronix?s catalysts, (2) developing a synthesis process for key pharmaceutical precursors used in cancer treatment, and (3) demonstrating the remediation application for industrial contaminants. The anticipated technical results will benchmark reactor characteristics and the catalytic metrics of the aforementioned processes.The broader commercial potential of this project is to facilitate the adoption of oxidative enzymes in synthesis and remediation applications because they can replace precious metal catalysts, toxic solvents, and energy intensive processes. Additional benefits translate to safer processes and products for manufacturers, consumers and the environment. ZYMtronix patent-pending technology is estimated to be substantially more efficient and cost effective to operate when compared with chemical systems, increasing enzyme activity, decreasing enzyme inhibition, and expanding the enzyme´s range of operable conditions. Combined with proprietary reactors being developed, the catalysts can be recycled for continuous use. ZYMtronix´s technology serves the fine chemicals, pharmaceutical, as well as the water remediation, markets applicable to oxidative enzyme processes.