CAREER: SusChEM: Copper-Catalyzed Aerobic Dehydrogenative C-C Bond Formation through sp3 C-H Bond Functionalization

该项目由NSF化学合成计划资助，支持印第安纳州普渡大学印第安纳波利斯分校（IUPUI）化学与化学生物学系葛海波教授的研究。葛教授的研究涉及制备重要有机分子的环境友好和原子效率方法。 这项研究的成功发展对合成有机，医药和农业化学领域产生了影响。 培训本科生和研究生进入劳动力市场也是该项目的一个关键部分。 正在开发一门新课程和一个新的本科生实验室实验。 这些课程的重点是过渡金属催化和杂环化学的课程整合。 该暑期本科生研究项目提高了IUPUI化学和生物化学专业学生的保留率和参与度，并促进他们进入就业市场或研究生/专业学校。葛教授正在开发在氧气气氛下使用铜催化反应将sp3杂化碳-氢键转化为碳-碳键的方法。这些直接的催化分解碳-碳键形成反应实现了多种起始底物中与杂原子（氮或氧）或亚氨基（碳-氮双键）相邻的sp3碳的选择性氧化。 该方法被扩展以实现各种杂环化合物的有效合成。 这些方法的非对映选择性和对映选择性（使用手性催化剂）变体也正在研究中。

This project, funded by the NSF Chemical Synthesis Program, supports the research of Professor Haibo Ge of the Department of Chemistry and Chemical Biology at Indiana University-Purdue University Indianapolis (IUPUI). Professor Ge's research involves environmentally-friendly and atom-efficient methods for preparing important organic molecules. The successful development of this research has an impact on the fields of synthetic organic, medicinal, and agricultural chemistries. The training of undergraduate and graduate students for entry into the workforce is also a key part of this project. A new course and a new undergraduate laboratory experiment are being developed. These courses focus on the integration of transition-metal-catalyzed and heterocyclic chemistry in the curriculum. The summer undergraduate research program improves retention and engagement among chemistry and biochemistry students at IUPUI, and facilitates their entry into the job market or graduate/professional school.Professor Ge is developing methods for the conversion of sp3-hybridized carbon-hydrogen bonds into carbon-carbon bonds using copper-catalyzed reactions conducted under an atmosphere of oxygen. These direct, catalytic dehydrogenative carbon-carbon bond-forming reactions achieve the selective oxidation of sp3 carbons adjacent to a heteroatom (nitrogen or oxygen) or an imino group (carbon-nitrogen double bond) in a variety of starting substrates. The processes are extended to achieve efficient syntheses of a variety of heterocyclic compounds. The diastereoselective and enantioselective (using chiral catalysts) variants of these processes are also being studied.