Collaborative Research: Data-Driven Smart Monitoring of Alzheimer's Disease via Data Fusion, Personalized Prognostics, and Selective Sensing

本项目的目标是开发一种数据驱动的阿尔茨海默病-S病(AD)智能监测方法。与正常老化相比，AD遵循加速降解的轨迹。对疾病轨迹的准确监测和预测对于许多预防性干预的成功至关重要。目前，还没有用于监测快速增长的临床前人群的一线筛查系统。虽然新兴的个性化健康筛查系统提供了对大量个人进行常规筛查的基础设施，但将这些系统的角色从被动的信息收集转变为智能监测以主动表征由个人-S风险因素形成的潜在复杂的时变疾病轨迹-是一个至关重要的挑战。本项目旨在开发这样一种智能监控系统。这种方法将为当今的网络基础设施配备强大的数据驱动的决策能力，以更好地管理临床前个体，导致更有效的有针对性的筛查和负担得起的护理，更好的治疗规划和管理，并提高患者和护理人员的生活质量。成功的实施将大大促进未来20年预计将有450万名临床前患者的检测工作。鉴于个性化筛查系统在其他领域的迅速采用，它的一般性也将影响对其他进步的医疗状况的监测。这项研究的跨学科性质涉及数据驱动的监测、预测、优化和医疗保健，这将使学生具备多样化的教育背景。还将通过新的课程模块、用于实施的在线软件工具包以及让未被充分代表的本科生和研究生参与研究体验方案来产生更广泛的影响。该项目的成功将显著促进数据驱动的监测、预测和选择性传感方面的最新水平，并为新兴的个性化筛查系统的科学基础做出贡献。具体地说，为了对疾病轨迹进行建模和量化，将通过开发非参数和半参数数据融合方案来合成来自多个生物标记物的退化信息，从而构建健康指数(HI)模型。然后，为了预测个性化疾病的发展轨迹，将开发个性化预测方法，通过发展多水平退化模型和贝叶斯更新方法，可以离线预测和在线更新个性化HI模型。利用个性化预测方法，将开发选择性传感方法，通过将新的贝叶斯网络模型与稳健的优化技术无缝集成，自适应地确定对HI的统计估计最有信息量的筛选测试。一个由五名具有不同但互补的研究背景的PI组成的团队将与美国两家领先的AD研究机构密切合作，开发、测试和验证这些方法。

The objective of this project is to develop a data-driven smart monitoring methodology of Alzheimer?s disease (AD). AD follows an accelerated degradation trajectory as compared to normal aging. Accurate monitoring and prognosis of the disease trajectory is critical for the success of many preventative interventions. Currently, no first-line screening system for monitoring the fast-growing preclinical population is available. While emerging personalized health screening systems provide the infrastructure to routinely screen massive numbers of individuals, it is an essential challenge to transform the role of these systems from passive information collection into smart monitoring to proactively characterize the underlying complex time-varying disease trajectory shaped by an individual?s risk factors. This project aims at developing such a ?smart monitoring? approach that will equip nowadays cyber infrastructure with powerful data-driven decision-making capabilities for better management of the preclinical individuals, leading to more efficient targeted screening and affordable care, better treatment planning and management, and improved quality of life for both patients and caregivers. Successful implementation will provide a substantial boost for the detection of the 4.5 million preclinical individuals anticipated in the next 20 years. Its generic nature will also impact monitoring of other progressive medical conditions, given the rapid adoption of personalized screening systems in other areas. The interdisciplinary nature of this research across data-driven monitoring, prognostics, optimization, and health care will prepare students a diversified education background. Broader impacts will be also generated through new curriculum modules, online software toolkits for implementation, and involving underrepresented undergraduate and graduate students in research experience programs.The success of the project will significantly advance the state of the art in data-driven monitoring, prognostics, and selective sensing, and contribute to the science base of the emerging personalized screening systems. Specifically, to model and quantify the disease trajectory, a health index (HI) model will be constructed by synthesizing the degradation information from multiple biomarkers via the development of non-parametric and semi-parametric data fusion schemes. Then, to predict the personalized disease trajectory, personalized prognostics methodologies will be developed that can offline predict and online update the personalized HI model via the development of multi-level degradation models and Bayesian updating approaches. Capitalizing on the personalized prognostics methodologies, selective sensing methodologies will be developed to adaptively identify the screening tests that are most informative for the statistical estimation of the HI via a seamlessly integration of a novel Bayesian network model with robust optimization techniques. A team of five PIs with diverse but complementary research backgrounds will be working closely with two leading AD research institutes in the U.S. to develop, test, and validate the methodologies.