New developments in velocity-map imaging mass spectrometry based on the Pixel Imaging Mass Spectrometry camera: Correlations between multiple ions and electrons and imaging molecular structure and following photoinduced processes on a femtosecond time sca

用光电子-光离子符合(PEPICO)和光离子-光离子符合(PIPICO)方法研究了光生反应的解离动力学。这两种技术都将受益于新开发的快速传感器，其中的原型目前正在布劳德教授的团队中实施。在我开始研究稍大的分子系统之前，我建议先检查一下装置中传感器的能力，使用众所周知的系统来描述仪器的特性。改进的符合技术将有助于加深对光诱导反应动力学的理解。此外，我还建议将快速传感器应用于二维样本的空间地图成像。利用快速检测系统，可以在显微镜模式下对整个样品区域成像，以及在单个飞行时间周期内检测所有出现的质量信号。这允许对样品阵列进行高效的高通量筛选，以优化条件或分析光反应，或快速识别和表征生物样品集，例如蛋白质。此外，我还建议将该技术应用于二维组织样本的分析，并改进方法以用于医学相关组织样本的实际应用。

The photoelectron-photoion coincidence (PEPICO) and photoion-photoion coincidence (PIPICO) methods are used to study the dissociation dynamics of photo-induced reactions. Both techniques will profit from newly developed fast sensors, of which prototypes are currently being implemented in the group of Prof. Brouard. I propose to examine the capabilities of the sensors in the setup, using well-known systems to characterise the instrument, before I start to investigate slightly larger molecular systems. The improved coincidence techniques will contribute to the enhanced understanding of photoinduced reaction dynamics. Further, I propose to apply the fast sensors to spatial-map imaging of two-dimensional samples. With the fast detection system, it becomes possible to image the whole sample area in the microscope mode, as well as detecting all occurring mass signals, in a single time-of-flight cycle. This allows for efficient high-throughput screening of sample arrays, either to optimise the conditions or analyse a photoreaction, or to quickly identify and characterise sets of biological samples, e.g. proteins. Moreover, I also propose to apply the technique to analyse two-dimensional tissue samples, and to refine the method for practical application on medically relevant tissue samples.