Nano Risk Analysis (II): A Workshop to Explore How a Multiple Models Approach can Advance Risk Analysis of Nanoscale Materials

PI：Joanne Shatkin建议编号：CBET-1446275纳米风险分析(II)：探索多模型方法如何推进纳米材料风险分析的研讨会，2014年9月15-16日，乔治华盛顿大学，华盛顿DCT他的提案是支持风险分析学会(SRA)召开一次公开的多方利益相关者研讨会，探讨将多种方法方法整合到ENM筛查级别的风险评估中，将于2014年9月15-16日在华盛顿特区的乔治华盛顿大学举行。尽管十年来一直在努力利用毒理学和暴露研究来帮助评估纳米材料的健康和环境风险，但在我们理解和量化来自工程纳米材料(ENM)的此类风险的能力方面仍然存在重大差距。一个迫在眉睫的差距是需要开发可靠的方法，通过筛选技术对新的ENM物质进行评估和分类。替代测试策略(ATS)可以包括高通量筛选方法(HTS)和其他方法，具有快速筛选大量和类型材料的潜力。然而，现有的和新出现的ATS对于ENM风险的定量估计还不够可靠。本研讨会旨在探索如何将不同的AT结合起来，创建一种多模型方法，以增加体外测试的置信度，以便可以依赖它们来决定在特定情况下是否需要对新的ENM进行更广泛的测试。除了来自研究和行业的技术专家和代表外，还邀请不同的环境、消费者、劳工和动物权利团体以及其他专业协会及其成员参加。与ENM风险评估相关的这种广泛的、横向的部门的参与将确保迅速传播讨论的结果，这些结果可以为纳米材料的健康和环境风险评估的进展提供信息和帮助。研讨会的主要目标是：(1)从“多模型”的角度评估高温超导和高温超导的科学状况；(2)评估使用高温超导/高温超导方法的数据用于筛选目的的能力；(3)评估使用一套自动测试方法放大证据权重的能力；(4)描述和处理与预测关系相关的不确定性；(V)征求不同利益攸关方对使用HTS/ATS进行ENM风险分析的筛查目的的观点；以及(Vi)为这些替代方法制定一套建议，以便在产品生命周期内关于ENM的环境、健康和安全决策中更广泛地采用这些替代方法。这次研讨会的独特贡献是将研究转化为使用ATS进行风险分析中筛选级决策的证据权重(SEEE)方法。研讨会的成果将是一套建议，报告给经合组织WPMN，并通过同行评议的出版物，说明如何在短期内切实应用这些方法，以改善政府和工业组织的环境决策。这种产出具有通过风险筛选办法进行转型的潜力，这些办法可促进更安全和更可持续的物质和技术开发。

PI: JoAnne ShatkinProposal Number: CBET - 1446275Nano Risk Analysis (II): A Workshop to Explore How a Multiple Models Approach can Advance Risk Analysis of Nanoscale Materials, September 15-16, 2014, George Washington University, Washington, DCThis proposal is for support of the Society for Risk Analysis (SRA) to convene a public, multi-stakeholder workshop exploring the integration of a multiple-methods approach into screening level risk-assessment of ENM, to be held September 15-16, 2014 at George Washington University in Washington, DC. Despite a decade of effort to use toxicology and exposure research to aid the assessment of health and environmental risks of nanomaterials, major gaps remain in our ability to understand and quantify such risks from engineered nanoscale materials (ENM). One pressing gap is the need is to develop reliable approaches for evaluating and classifying novel ENM substances through screening techniques. Alternative Testing Strategies (ATS), which can include high throughput screening methods (HTS), and other methods, have the potential for rapid screening of large numbers and types of materials. However, existing and emerging ATS are not yet reliable enough for quantitative estimation of ENM risk. This workshop is to explore ways in which the different ATS may be combined to create a multiple models approach that can increase the confidence in vitro tests so that they can be relied upon for deciding whether more extensive testing of novel ENM are needed in specific cases. In addition to technical experts and representatives from research and industry, diverse environmental, consumer, labor, and animal rights groups, as well as other professional societies and their members are also invited to participate. The participation of such broad, horizontal sectors associated with ENM risk assessments will assure the rapid dissemination of results of the discussions, results that can inform and aid the progress of assessment of health and environmental risks of nanomaterials.The main objectives of the workshop are to: (i) assess the state of the science on HTS and ATS from a "multiple models" perspective; (ii) evaluate the ability to use data from ATS/HTS methods for screening purposes; (iii) assess the ability to use a suite of ATS methods to amplify the Weight of Evidence; (iv) characterize and address uncertainty associated with predictive relationships; (v) elicit the perspectives of diverse stakeholders about the use of HTS/ATS for screening purposes in risk analysis of ENM; and (vi) develop a set of recommendations for these alternative approaches to become more widely adopted for environmental, health and safety decision making about ENM across the product life cycle. The unique contribution of this workshop is the translation of research into a Weight of Evidence (WoE) approach using ATS for screening-level decisions in risk analysis. The output of the workshop will be a set of recommendations reported to the OECD WPMN and via peer reviewed publications about ways in which these approaches may be practically applied in the near term to improve environmental decision making by governmental and industrial organizations. Such an output holds potential for transformation through risk screening approaches that promote safer and more sustainable substance and technology development.