RCN: A Network to Promote Comparative Genome to Phenome Analysis

了解生物体的DNA（基因组）与基因组表达产生的表型特征（表型组）之间的关系是生物学的核心挑战。来自多个物种的高通量测序和表型数据为基因组与表型数据的比较分析提供了机会。该奖项的目标是建立一个基因组到表型网络（G2PN）研究合作网络（RCN），旨在促进脊椎动物和无脊椎动物的比较分析，以丰富我们对基因组和表型之间关系的理解。G2PN将汇集使用不同实验方法的研究小组，以了解基因组最终如何表现出这种现象。G2PN将为科学家提供必要的工具，以利用比较基因组学方法来理解基因组与表型之间的关系。此外，G2PN的活动还将为本科生、研究生和博士后提供比较生物学和基因组与现象组关系方面的培训。将特别鼓励为历史上代表性不足的群体服务的大学和学院的研究人员参与。G2PN亦会提供教育单元，进一步加强学生在G2PN概念方面的训练。G2PN开发的所有资源都将免费提供给科学界，在科学会议上进行交流，并在同行评议的期刊上发表。G2PN的一个主要目标将是鼓励研究人员离开他们的孤岛，发展合作团队，利用比较方法来增强我们对基因组与表型关系的理解。G2PN RCN的目标包括：与研究各种动物的科学家建立一个国际G2PN；通过促进实验方法、数据和元数据收集以及生物信息学分析的标准化，将直接促进比较研究发展的G2PN活动；通过国际会议、网站、出版物和社交媒体，促进来自不同专业的科学家之间的新合作和提案；并通过开发使用多种教育方式的培训模块来促进对比较基因组研究的理解。最终，这个RCN将提高我们对选择压力、基因组变化和表型结果之间关系的理解。这个RCN开发的标准将发现其适用性远远超出了直接受G2P网络影响的科学。这些标准将促进实验室工作和跨大范围物种和研究的数据可比性。

Understanding the relationship between an organism's DNA (the genome) and the set of phenotypic characteristics that result from genomic expression (the phenome) is a central challenge in biology. High throughput sequencing and phenotypic data from multiple species provides an opportunity for comparative analysis of genome to phenome data. The objective of this award is to develop a Genome to Phenome Network (G2PN) Research Collaboration Network (RCN) aimed at promoting comparative analysis of vertebrate and invertebrate animals to enrich our understanding of the relationship between genomes and phenomes. The G2PN will bring together groups using diverse experimental approaches to understand how the genome ultimately manifests the phenome. The G2PN will provide tools necessary for scientists to exploit comparative genomics approaches to understand genome to phenome relationships. In addition, the activities of the G2PN will provide training for undergraduates, graduate students and post-doctoral fellows in the science of comparative biology and genome to phenome relationships. Participation of researchers from universities and colleges serving historically underrepresented groups will be particularly encouraged. The G2PN will also generate educational modules to further enhance student training in G2P concepts. All of the resources developed by the G2PN will be freely available to the scientific community, communicated at scientific meetings, and published in peer-reviewed journals.A major objective of the G2PN will be to encourage researchers to leave their silos and develop collaborative teams that will exploit comparative approaches to enhance our understanding of genome to phenome relationships. The G2PN RCN goals include: Establishing an international G2PN with scientists studying a diverse range of animals; G2PN activities that will directly foster the development of comparative studies by promoting standardization of experimental approaches, data and metadata collection and bioinformatic analyses; promoting new collaborations and proposals among scientists from different specialties through international meetings, web sites, publications and social media; and promoting understanding of comparative genomic studies through the development of training modules using diverse educational modalities. Ultimately, this RCN will improve our understanding of the relationships between selective pressures, genomic changes and phenotypic outcomes. The standards developed by this RCN will find applicability far beyond the science directly affected by the G2P network. These standards will facilitate laboratory work and data comparability across a broad range of species and studies.