SBIR Phase I: Wireless pill bottle with dose-time reminders and a monitoring system which prompt patients to take medication as directed

这个小企业创新研究（SBIR）第一阶段项目的更广泛的影响/商业潜力是通过改善药物服用来改善人类健康。虽然药物可以显著改善人类健康，但只有在正确服用的情况下才能实现。然而，许多消费者往往不能正确服用药物。通过向卫生网络提供一种简单、具有成本效益的服药监督方法，集中改善患者的依从性将直接导致住院人数减少、健康状况更好、长期结果得到改善。通过将依从性监测的负担从患者身上转移，昂贵而有效的干预措施可以只集中在那些真正需要帮助的患者身上，这既可以降低劳动力成本，又可以提高门诊服务健康网络的收入潜力。该产品基于一个简单的电子剂量提醒和监测系统，以改善和鼓励自我管理药物服用，同时得到数据指导的医疗保健干预的支持。系统？的无线数据传输允许使用客观的服药信息进行实时测量和干预，这是目前医疗保健系统无法实现的一个过程，将减少每年因不良服药而导致的数十亿美元的可避免住院费用。拟议的项目将集中于开发一个完整的无线服药依从性和监测系统。不依从性已被证明每年导致1000亿美元的可避免的住院治疗，估计不依从性的总成本高达2900亿美元。只有50%至60%的患者按照指示坚持服药。现有的依从性系统没有解决该问题，因为它们实施起来昂贵，需要独特的设备或通信技术，需要患者记住并输入他们的依从性数据，不能及时提供有用的可操作信息，并且不能提供患者依从性的长期视图，以及其他因素。该项目的研究目标是充分开发电路，数据桥接设备和编程系统的蓝牙低功耗的坚持监测系统。然后，系统组件将在商业和家庭环境中进行测试，模拟现实世界的使用和实施。将记录和优化系统性能和功能特性。我们预计，已完成的项目将提供一个功能齐全的药物依从性系统，可用于临床研究和患者用药的商业评估。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to improve human health through improved medication taking. While medications can provide significant improvements to human health, they can only do so if taken properly. Many consumers however often fail to take their medications correctly. By providing health networks a simple, cost-effective approach to medication taking oversight, focused improvement in patient adherence will directly result in fewer hospitalizations, better sustained health and improved long-term outcomes. By moving the burden of adherence monitoring away from the patient, expensive yet effective interventional practices can be focused only on those patients who actually need help, when they need it. This will both reduce labor costs and improve revenue potential for outpatient-services health networks. The product is based upon a straightforward, electronic dose-reminder and monitor system to improve and encourage self-management of medication taking while being supported by data-directed healthcare interventions. The system?s wireless data transmission allows for real-time measurement and intervention using objective medication-taking information, a process that is currently unavailable to healthcare systems and will reduce the billions of dollars spent annually in avoidable hospitalizations due to poor medication taking.The proposed project will focus on developing a complete, wireless, medication adherence and monitoring system. Non-adherence has been shown to lead to $100 billion in avoidable hospitalizations each year with an estimated total cost of non-adherence to be as high as $290 billion a year. Only 50% to 60% of patients adhere to their medication regimens as directed. Existing adherence systems are not solving the problem because they are expensive to implement, require unique equipment or communication technology, requires the patient to remember and input their adherence data, fails to provide actionable information in time to be useful and doesn't provide a long term view of patient adherence, amongst other factors. The project's research objectives are to fully develop the circuitry, data bridging device and programming system for a Bluetooth low energy based adherence monitoring system. The system components will then be tested in a commercial and at-home setting that will mimic real-world use and implementation. System performance and functional characteristics will be recorded and optimized. We anticipate that the completed project will provide for a fully functional, medication adherence system that can be implemented for both clinical study and commercial evaluation of patient medication taking.