Molecular mechanism of the heat shock transcription factor Hsf1 (09)

TP 09研究细胞对蛋白毒性应激的反应如何在分子水平上调节。该项目的一个重点是分析单体和三聚体人类热休克转录因子Hsf1的结构，并开发基于Hsf1的生物发光共振能量转移传感器，可用于筛选Hsf1激活和Hsf1抑制小分子，作为癌症和神经退行性疾病的治疗药物。第二个重点是通过翻译后修饰和相互作用蛋白质调节Hsf1激活和衰减的分子机制。

TP09 investigates how the response of cells to proteotoxic stress is regulated at a molecular level. One focus of the project is the analysis of the structure of monomeric and trimeric human heat shock transcription factor Hsf1 and the development of an Hsf1 based bioluminescence resonance energy transfer sensor that could be used to screen for Hsf1 activating and Hsf1 inhibiting small molecules as therapeutics for cancer and neurodegenerative diseases. The second focus is the molecular mechanism of the modulation of Hsf1 activation and attenuation by posttranslational modifications and interacting proteins.