Aesthetic and functional outcome after oncoplastic breast conserving surgery

美观和功能预后是影响保乳术后生活质量的重要因素。为了测量这些结果，需要有效的研究工具。没有有效的测量，不可能系统地发展和改进保乳技术。该项目的目的是进一步发展现有的和已经检查过的仪器（客观的基于软件的照片分析和患者问卷），以便1。研究长期随访期间器械变化的敏感性（使用现有前瞻性队列研究的患者，术后1-4年）。到目前为止，我们只能研究短期结果，但长期结果更为重要。查明上述研究工具是否能够确定临床定义的队列亚组的长期变化是非常重要的。迫切需要对患者问卷的重测信度进行分析。2. 改善由年龄、肿瘤大小、肿瘤位置、乳房大小和形状定义的亚组中美学和功能结果测量的经验分布的知识，为规划未来的研究提供有效的估计。在项目的这一部分中，我们需要分析不同的手术程序和临床情况（年龄、肿瘤大小、肿瘤位置、乳房大小和形状等）对上述两种仪器测量的美学和功能结果的影响，以探索它们区分这些情况的能力。

Aesthetic and functional outcome are important influencing factors on quality of life after breast conserving therapy. To measure these outcomes, valid study instruments are needed. Without valid measurements a systematic development and amelioration of breast conserving techniques is not possible. Aim of the project is to further develop the existing and already examined instruments (an objective software-based analysis of photographs and a patient questionnaire) in order to 1. study the sensitivity of changes of the instruments during a long term follow-up (using the patients of an existing prospective cohort study after 1-4 years after the surgery. Until now we could only study the short term outcomes, but the long term results are the far more important ones. It is very important to find out if the above mentioned study instruments are able to determine long term changes within clinically defined subgroups of the cohort. Analysis of re-test reliability of the patient questionnaire is urgently needed. 2. ameliorate the knowledge of the empiric distribution of the measurements of aesthetic and functional outcome in subgroups defined by age, tumor size, tumor location, breast size and shape to have valid estimates for planning future studies. Within this part of the project we need to analyse the influence of the different surgical procedures and clinical situations (age, tumor size, tumor location, breast size and shape, etc.) on aesthetic and functional outcome measured by to two mentioned instrument to explore their ability to differentiate between these situations.