MRI: The Acquisition of Seahorse to measure Mitochondrial Metabolism will fuel Biological Research at an HBCU

向特拉华州立大学颁发了一个奖项，以加强几个领域的研究，同时也为本科生教育和培训做出贡献。仪器(SeaHorse，Argilent Technologies，Inc.)使研究人员能够测量细胞的能量和新陈代谢。除了为本科生提供研究培训外，这种设备也将是重新设计的生物核心课程的关键组成部分。该项目的绩效指标将试点以课程为基础的本科生研究体验(CURE)，为学生提供参与真实研究的机会。让学生接触到这样的研究经历将使他们对科学职业有更积极的看法，并提高STEM领域的保留率。这一仪器将支持一个不同的、跨学科的研究团队，他们的研究重点是了解构成细胞能量收支的遗传、分子和细胞机制(海马)。海马号将为四个不同的项目提供服务。一个项目调查了线粒体功能和TDP-43之间的联系，TDP-43是一种核糖核蛋白，与多种形式的神经退行性变有关。另外两个项目研究多巴胺在与神经退变相关的代谢功能障碍中的作用，一个项目侧重于在果蝇模型中鱼藤酮毒性，另一个项目调查SUMO化在防止线粒体功能障碍和细胞死亡方面的作用。第四个项目研究CD44的作用，CD44是一种细胞表面糖蛋白，在低氧条件下细胞代谢重编程为糖酵解过程中起重要作用。

An award is made to Delaware State University to enhance research in several areas while also contributing to undergraduate education and training. The instrumentation (Seahorse, Argilent Technologies, Inc.) allows researchers to measure the energy and metabolism of the cell. In addition to providing training of undergraduates in research, this equipment will also be a critical component of the redesigned core curriculum in biology. The PIs of this project will pilot a course-based undergraduate research experience (CURE) that will provide an opportunity for students to participate in authentic research. Exposing students to such research experiences will give them a more positive view of scientific careers and enhance retention rates in STEM fields. This instrumentation will support a diverse, interdisciplinary team of investigators whose research focuses on understanding the genetic, molecular and cellular mechanisms that underlie energy budgets in cells (Seahorse). The Seahorse will serve four distinct projects. One project investigates the connection between mitochondrial function and TDP-43, a nuclear ribonucleoprotein that has been implicated in many forms of neurodegeneration. Two other projects investigate the role of dopamine in metabolic dysfunction related to neurodegeneration, one focusing on rotenone toxicity in a drosophila model, while the other project investigates the role of SUMOylation in preventing mitochondrial dysfunction and cell death. A fourth project investigates the role of CD44, a cell-surface glycoprotein important in the metabolic reprogramming of cells to glycolysis under hypoxic conditions.