New Strategies for Monitoring DNA-Anticancer Drug Interactions

非常成功的顺铂通过与DNA结合并部分解开或弯曲DNA来发挥作用。由于顺铂的成功，人们正在开发替代抗癌药物，以减少患者的副作用。开发替代药物的关键之一是对新线索的疗效进行快速筛选。这项拟议的研究将开发使用新型DNA生物传感器监测DNA药物结合、DNA损伤和DNA修复的新技术。生物传感器技术的新颖性将是使用通过DNA的电荷转移的调制作为一种方法来确定由于这些事件发生在DNA中发生的结构变化。

The highly successful cisplatin works by binding to DNA and partially unwinding or bending the DNA. As a consequence of the success if cisplatin, alternative anticancer drugs are being developed with reduced side effects for patients. One of the bottom necks in the development of alternative drugs is rapid screening of the efficacy on new leads. The proposed research will develop new technologies for monitoring DNA-drug binding, DNA damage and DNA repair using novel DNA biosensors. the novelty of the biosensor technology will be to use the modulation of charge transfer through DNA as a method for determining the structural changes that occur in DNA due to these events occurring.