MRI: Acquisition of a 700 MHz high field NMR spectrometer

美国新罕布什尔大学（UNH）获得了一项奖励，以支持购置一台700兆赫的核磁共振（NMR）光谱仪。700 MHz核磁共振将配置用于溶液和固态核磁共振研究，具有高灵敏度和易用性，可以进行生物和其他低灵敏度分子的结构和动力学研究。新仪器将服务于联合国大学6个系和3个学院的18个研究项目，将不同的研究人员聚集在一起。它还将服务于该地区的其他学院和大学，并将通过远程登录在全国范围内访问。该仪器将增加高级培训机会，特别是为追求高级学位的学生，准备下一代核磁共振波谱学家。此次收购为UNH和新英格兰北部地区的结构生物学、化学和材料科学项目提供了广泛的研究支持。研究课题将包括抗冻蛋白、支架蛋白、光感受器酶、合成酶、弹性蛋白样聚合物和蛋白质-聚合物杂交体的研究。核磁共振数据将与建模和模拟数据集成，以获得蛋白质动力学和相互作用的整体视图。固态核磁共振将用于表征固体样品的结构和动力学，包括膜相关蛋白质、蛋白质-冰混合物、聚合物和纳米材料。这些研究的数据将发表在同行评议的期刊上，在科学会议上提出，用于课程设置，并在公共宣传活动中加以利用。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to the University of New Hampshire (UNH) to support the acquisition of a 700 MHz Nuclear Magnetic Resonance (NMR) spectrometer. The 700 MHz NMR will be configured for solution and solid state NMR studies with high sensitivity and ease-of-use to enable structural and dynamics studies of biological and other low sensitivity molecules. The new instrument will serve 18 UNH research programs from 6 departments and 3 colleges, bringing together a diverse group of researchers. It will also serve other colleges and universities in the region and will be nationally accessible via remote login. The instrument will enhance advanced training opportunities, especially for students pursuing advanced degrees, preparing the next generation of NMR spectroscopists. Research enabled by the acquisition encompasses a broad range of structural biology, chemistry, and materials science based projects at UNH and in the northern New England region. Research topics will include studies of antifreeze proteins, scaffold proteins, photoreceptor enzymes, synthetic enzymes, elastin-like polymers, and protein-polymer hybrids. NMR data will be integrated with modelling and simulation data to gain a holistic view of protein dynamics and interactions. Solid state NMR will be used to characterize the structure and dynamics of solid samples, including membrane associated proteins, protein-ice mixtures, polymers, and nanomaterials. Data from these studies will be published in peer-reviewed journals, presented at scientific meetings, used in course offerings, and leveraged in public outreach activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.