Excellence in Research: Unlocking the Synthetic Power of Regioselective and Stereoselective Carbon Carbon Bond Formations for Multicomponent Reactions in Heterocycle Synthesis

HBCU卓越研究计划支持Fenghai Guo教授的项目。Fenghai Guo教授是温斯顿塞勒姆州立大学化学系的教员。在拟议的项目中，郭教授和他的团队正在开发新的反应，允许有效地构建新的碳-碳键。这些键存在于氮、硫和氧基环骨架中，这些环骨架形成许多药用活性分子的核心。这种化学方法利用了金属基试剂，降低了反应的能量屏障，这些反应可以在一个步骤中从多个更小、更容易获得的构建模块组装更大的分子。除了这些科学目标外，该研究项目还为来自代表性不足群体的STEM本科生提供研究经验。为此，郭教授的研究小组位于温斯顿塞勒姆州立大学。除了与温斯顿塞勒姆州立大学的本科生合作外，PI和他的团队还参与了外展活动，为高中实习生提供了在合成化学领域进行研究的机会。 碳碳键的形成在形成复杂杂环的碳骨架中是非常有价值的。在这个项目中，郭教授正在开发多组分反应，包括串联的1，4-和1，6-共轭加成-酰化序列和串联的1，4-，1，6-共轭加成与氧化偶联反应。这些反应导致多个C-C键和立体中心的产生。该研究在金属催化共轭加成反应的选择性和新杂环化合物的生成方面产生了新的知识。该方法的实用性正在说明其应用程序的生物活性，复杂的杂环系统的合成。工作中心的教育更广泛的影响是为来自代表性不足群体的学生提供机会，以获得合成化学的研究经验。温斯顿塞勒姆州立大学是许多非洲裔美国人和代表性不足的少数民族学生进入科学的门户。通过这种方式，郭先生的团队非常适合在教育领域发挥更广泛的影响力。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响力审查标准进行评估，被认为值得支持。

The HBCU Excellence in Research program supports the project by Professor Fenghai Guo. Professor Fenghai Guo is a faculty member in the Department of Chemistry at Winston Salem State University. In the proposed project, Professor Guo and his group are developing new reactions that allow for efficient construction of new carbon-carbon bonds. The bonds are found in the nitrogen, sulfur, and oxygen based ring skeletons that form the core of many medicinally active molecules. The chemistry takes advantage of metal-based reagents that lower the energetic barrier for reactions that assemble larger molecules from multiple smaller, more readily available building blocks in a single step. In addition to these scientific goals, the research project provides research experiences for STEM undergraduates who are from underrepresented groups. To that end, Professor Guo's group is ideally located at Winston Salem State University. In addition to working with the undergraduate students at Winston Salem State University, the PI and his group are involved in outreach activities that provide high school interns with opportunities to pursue research in the area of synthetic chemistry. Carbon carbon bond formation is very valuable in forming the carbon skeletons of complex heterocycles. In this project, Professor Guo is developing multicomponent reactions that consist of tandem 1,4- and 1,6-conjugate addition-acylation sequences and tandem 1,4-, 1,6-conjugate additions coupled with oxidative coupling reactions. The reactions lead to the generation of multiple C-C bonds and stereocenters. The research is generating new knowledge in terms of the selectivity available to metal catalyzed conjugate addition reactions and the generation of new heterocyclics. The utility of the method is being illustrated by its application to the synthesis of bioactive, complex heterocyclic ring systems. The educational Broader Impact of the work centers on the opportunities it is providing for students from underrepresented groups to gain research experience in synthetic chemistry. Winston Salem State University serves as a gateway to the sciences for many African American and underrepresented minority students. In this way, the Guo group is ideally positioned to have a significant educational Broader Impact.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.