I-Corps: N-Halamine Antimicrobial Coatings

I-Corps项目更广泛的影响/商业潜力在于，它将为开发一种新型可充电电池奠定基础。易于应用于各种表面并被各种表面吸收的抗菌涂层产品，以防止污染物的传播。在食品工业中，这种抗菌涂层产品可以帮助减少因食源性疾病暴发引起的公共卫生风险和负担，并减少因腐败或病原微生物污染给食品工业造成的经济损失。对于医疗保健行业来说，这种涂层可以为防止耐药微生物或超级细菌的交叉污染提供一种低成本和高效的选择。在医院和卫生保健机构的公共环境表面。如果新产品开发成功并投入市场，将给社会带来经济回报，提高人类的生活质量。最终，它可以帮助加强美国食品和医疗保健行业，并减少政府公共卫生预算的成本。这个I-Corps项目是基于一种新型的n -卤胺类抗菌涂层材料，这种材料可以“再充电”。通过简单的含氯漂白剂处理。这种高分子材料的设计是为了克服目前抗菌涂层的几个缺点。我们的抗菌涂层材料有两个关键的创新：1)广泛、有效和可充电的杀菌功能；2)对任何材料、大小和形状的表面都有很强的吸光度。我们已经做了大量的工作来合成、配制和制作基底材料（不锈钢和塑料）涂层的原型，这些材料通常用于制造食品和医疗保健设备和设施。我们还扩大了对实际食品设备部件的涂层和测试，包括金属管道和塑料传送带。初步数据很有希望。我们计划不久在食品制造厂试用我们的N-halamine涂层。最终，实际应用环境中的复杂问题和挑战将激发更深入的基础研究，以促进对食品科学，环境微生物学和抗菌化学的认识和理解。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this I-Corps project is that it will lay the foundation for developing a novel ?rechargeable? antimicrobial coating product that is easily applied to, and absorbed by, a wide variety of surfaces, to prevent the transmission of contaminants. In the food industry, this antimicrobial coating product could help to reduce the public health risk and burden due to foodborne illness outbreaks and reduce economic losses for food industry due to spoilage or pathogenic microorganism contamination. For the health care industry, the coating could provide a low-cost and highly-effective option for preventing the cross-contamination of drug-resistant microorganism or ?superbugs? on communal environmental surfaces in hospitals and health care facilities. If new products are successfully developed and go to market, it will bring economical reward to the society and improve human life quality. Ultimately, it can help to strengthen the US food and health care industries and reduce the cost of government budget for public health. This I-Corps project is based on a novel N-halamine-based antimicrobial coating material that can be ?recharged? through simply treating with chlorine bleach. This polymer material was designed to overcome several shortcomings of current antimicrobial coatings. There are two critical innovations of our antimicrobial coating material: 1) broad, potent, and rechargeable biocidal function; 2) strong and versatile absorbance on surfaces regardless of materials, sizes, and shapes. We have done a significant amount of work to synthesize, formulate, and prototype the coatings on substrate materials (stainless steels and plastics) that are commonly used for fabricating food and health care equipment and facilities. We have also scaled up for coating and testing on real food equipment parts including metal pipes and plastic conveyor belts. The preliminary data are very promising. We are planning to do trials in the food manufacturing plants using our N-halamine coating soon. Ultimately, the complex problems and challenges in real application environments will inspire more intensive fundamental research to advance knowledge and understanding in food science, environmental microbiology, and antimicrobial chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.