Conference Support for the 2019 Ribosome Meeting; January 6-10, 2019, Merida, Mexico

该奖项将支持职业研究人员早期参加核糖体结构和功能会议，该会议将于2019年1月6-10日在墨西哥梅里达的嘉年华美国酒店举行。会议的一个重要目的是为早期职业研究人员提供帮助他们发展专业技能的经验。会议的形式是演讲、海报会议和非正式会议相结合。这种形式促进了正式和非正式环境中的科学交流，并为与核糖体研究领域的领导人建立网络联系提供了机会。蛋白质合成是由核糖体催化的，核糖体是一种古老的进化保守的细胞机器。尽管近几十年来人们对蛋白质合成的机制有了基本的了解，但翻译的许多方面仍然在很大程度上没有得到回答。这些方面包括转位过程中的核糖体动力学、tRNA选择和多肽释放、翻译的各个步骤的动力学、许多蛋白质合成抑制剂的作用模式等。会议的一个主要目标是将致力于翻译不同方面的研究人员聚集在一起，探索不同的实验方法，使用不同的实验模型。与核糖体相关的最新发现将在围绕主题组织的10个科学会议上公布。科学计划将展示先进的技术和多学科方法的使用，以解决与基因表达和蛋白质合成相关的关键生物学问题。除了口头和海报演示外，组织者还计划通过一本主流科学期刊的特刊来传播这一信息，其中有受邀的演讲者和受训人员撰写的章节。这一奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award will support early career researcher attendance at the Ribosome Structure and Function Meeting, which will be held at the Fiesta Americana Hotel in Merida Mexico on January 6-10, 2019. An important aim of the conference is to provide early career researchers with experiences that help them develop professional skills. The format of the conference is a combination of talks, poster sessions and informal meetings. This format promotes scientific exchange in both formal and informal settings, and provides opportunities for networking with leaders in the field of ribosome research. Protein synthesis is catalyzed by the ribosome, the ancient and evolutionary conserved cellular machine. Although recent decades have brought a basic understanding of the mechanisms of protein synthesis, many aspects of translation remain largely unanswered. These aspects include the ribosome dynamics during translocation, tRNA selection and peptide release, the kinetics of individual steps of translation, the modes of action of many protein synthesis inhibitors and many others. An overarching goal of the meeting is to bring together researchers working on different aspects of translation, exploiting different experimental approaches and using different experimental models. The most recent discoveries related to the ribosome will be presented within 10 scientific sessions structured around thematic topics. The scientific program will showcase advanced techniques and the use of multidisciplinary approaches for solving key biological problems related to gene expression and protein synthesis. In addition to the oral and poster presentations the organizers plan to disseminate the information through a special volume of one of the mainstream scientific journals, with chapters written by invited speakers and trainees.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.