Finding Your Inner Modeler-year 3

细胞生物学的主要问题之一是，特定分子或细胞事件的详细知识不能跨时间和空间整合，研究人员缺乏对一个事件如何与另一个事件相关或影响另一个事件以导致整体细胞反应的理解。仅靠实验就很难理解特定的原子或分子反应是如何导致整体细胞行为的，而需要计算模型来显著推进我们的理解。由该奖项资助的研讨会的主要目标是通过促进实验细胞生物学家和计算建模人员之间的跨学科合作，促进管理细胞分化和动态平衡的生物物理规律的发现。该研讨会旨在为细胞生物学家和计算建模人员提供独特的机会，共同开发对细胞的预测性理解。研讨会还为参与的研究人员提供了独特的教育体验。组织者将与专业协会合作，确保从代表性不足的群体中招聘教师，以及研究生、博士后和其他职业早期专业人员。该奖项将为2017年至2018年由美国国家科学基金会MCB奖1649160支持的极其成功的“寻找你的内在模特儿(FYIM)”研讨会的第三年延长提供资金。第三年研讨会的目标是使用两天的形式来继续最初提案中阐明的目标：1)激发目前没有使用这种方法的科学家对计算建模的兴趣；2)促进细胞生物学家和计算建模人员之间形成跨学科合作；以及3)开发一个信息和指导网络，为细胞生物学家和计算科学家提供关于如何开始合作、联系谁以及支持合作的可用资源的建议。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

One of the major problems in Cell Biology is that detailed knowledge of specific molecular or cellular events is not integrated across time and space, and investigators lack the understanding of how one event relates to or influences another to result in the totality of cellular responses. Understanding how a specific atomic or molecular reaction results in the overall cellular behavior is extremely difficult by experimentation alone, and computational modeling is required to significantly advance our understanding. The main goals of the workshop funded by this award are to promote the discovery of biophysical laws that govern cellular differentiation and homeostasis by promoting the interdisciplinary collaborations between experimental cell biologists and computational modelers. The workshop aims to provide unique opportunities for cell biologists and computational modelers to work together to develop predictive understanding of the cell. The workshop also provides a unique educational experience for researchers who participate. Organizers will work with professional societies to ensure the recruitment of faculty from underrepresented groups as well as graduate students and postdocs and other early career professionals.This award will provide funding for a 3rd year extension of the extremely successful "Finding your Inner Modeler (FYIM)" workshops supported by the NSF MCB Award 1649160 during 2017 and 2018. The vision for the 3rd year workshop is to use the 2-day format to continue the goals articulated in the original proposal to: 1) stimulate interest in computational modeling among scientists currently not using this approach; 2) promote the formation of interdisciplinary collaborations between cell biologists and computational modelers; and 3) develop an information and guidance network to provide advice to cell biologists and computational scientists on how to start a collaboration, who to contact, and what resources are available to support collaborations.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.