SBIR Phase I: Internet-Connected Urinalysis System for Passive Health Monitoring

小型企业创新研究(SBIR)第一阶段项目的更广泛影响是，通过开发用于个性化饮食建议、早期疾病诊断和远程患者监测的被动健康和健康监测系统，帮助管理和预防非传染性慢性病。根据2019年全球疾病负担更新，全球五分之一以上的死亡是由不合理的饮食摄入造成的，这使其成为最大的可预防疾病风险因素。数十年的研究表明，跟踪营养摄入量可以更好地了解饮食摄入模式，改善营养健康。然而，尽管饮食跟踪移动应用很受欢迎，但它们并不准确，负担过重，因此往往会导致辞职。此外，在诊断大多数慢性病之前等待健康并发症的出现会缩短健康寿命，并导致更昂贵的医疗干预措施。社会上需要一种被动的营养和健康监测设备，帮助个人在常规基础上识别营养不良的模式，以指导终身行为变化，并及早识别疾病的生物标志物。这一平台技术将降低与大多数重大慢性病相关的发病率和死亡率，降低医疗成本，并减少生产力损失。拟议的项目将解决将无线电化学生物传感器测试平台集成到厕所进行被动尿液分析测试的可行性。更好的预防性医疗保健要求个人在出现临床问题之前很久就定期监测健康和福祉。然而，让个人进行一致的、例行的诊断评估是极其困难的。对健康数据进行常规监测的最有效途径是通过普及性测试，在这种测试中，尽可能不存在个人S的负担。使用配有生物传感器的联网智能马桶进行无处不在的、被动的和常规的家庭尿液检测，这在临床和商业上都有机会。关键技术障碍包括开发能够可靠地收集和稀释标准化尿液的系统、污染物核算、开发用于被动检索、转换、测试和存储一次性电化学生物传感器的坚固的机电组件、生物识别用户身份以及无线数据传输能力与智能电源管理的集成。与错误的测试周期启动、错误的生物传感器操作、稀释和污染核算以及错误的用户识别相关的错误率将被量化，而电化学生物传感器？现场测试结果将与台式测试结果进行比较。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is to help manage and prevent non-communicable chronic diseases by developing a passive health and wellness monitoring system for personalized dietary recommendations, early disease diagnosis, and remote patient monitoring. According to the 2019 Global Burden of Disease Update, suboptimal dietary intake is responsible for more than 1 out of every 5 deaths globally, making it the greatest preventable disease risk factor. Decades of research have shown that tracking nutritional intake can lead to better awareness of dietary intake patterns and improve nutritional health. Yet diet-tracking mobile apps, despite their popularity, are inaccurate and overly burdensome and thus often lead to quitting. In addition, waiting for health complications to develop before diagnosing most chronic diseases reduces healthspans and leads to more costly healthcare interventions. There is a societal need for a passive nutrition and health-monitoring device for helping individuals recognize patterns of malnutrition on a routine basis for guiding lifelong behavior change and identifying biomarkers of disease early. This platform technology will reduce morbidity and mortality associated with most major chronic diseases, decrease healthcare costs, and reduce lost productivity.The proposed project will address the feasibility of integrating a wireless, electrochemical biosensor testing platform into a toilet for passive urinalysis testing. Better preventative healthcare requires individuals to monitor health and wellbeing routinely, long before clinical problems arise. Yet getting individuals to perform consistent, routine diagnostic evaluations is exceedingly difficult. The most effective route for routine monitoring of health data is through pervasive testing where the individual?s burden is as nonexistent as possible. There is a clinical and commercial opportunity for ubiquitous, passive, and routine home urine testing using an internet-connected smart-toilet equipped with biosensors for accurate urine-testing. Key technical hurdles include the development of a system capable of reliable urine collection and dilution normalization, contamination accounting, the development of a robust mechatronic sub-assembly for passively retrieving, translating, testing, and storing disposable electrochemical biosensors, biometric user identification, and integration of wireless data transfer capabilities with smart power management. Error rates associated with false test cycle starts, faulty biosensor manipulation, dilution and contamination accounting, and false user identification will be quantified, and the electrochemical biosensors? in situ test results will be compared against benchtop equivalents.?This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.