Secreted fungal proteins in immune evasion and pathogenicity (C06)

白念珠菌通过分泌免疫逃避蛋白来控制免疫反应，这些蛋白有助于真菌致病，如Pra1。在第一个资助期，我们确定了真菌免疫逃逸的新机制和/或介体，这是由于抑制天然免疫和获得性免疫所致。此外，我们还产生了针对这些免疫逃避蛋白的单抗。在下一个资助期，我们将继续进行体外研究，并将分析扩展到小鼠的真菌免疫逃逸。此外，我们将在白色念珠菌感染的小鼠模型中评估我们的抗真菌单抗。

C. albicans controls the immune response by secreting immune evasion proteins that contribute to fungal pathogenicity like Pra1. During the first funding period we identified novel mechanisms and/ or mediators of fungal immune escape resulting from inhibiting both innate and adaptive immunity. Further, we have generated monoclonal antibodies (mAbs) against these immune evasion proteins. In the next funding period, we will continue the in vitro studies and extend the analyses to fungal immune escape in mice. Moreover, we will evaluate our anti-fungal mAbs in mouse models of C. albicans infections.