Environmentally responsive nanogels for drug delivery (A04)

该项目致力于开发水溶性/分散性刺激响应型纳米软颗粒，即所谓的纳米凝胶，它应该能够：(I)包裹地塞米松、他克莫司、托法替尼和依那西普；(Ii)将它们输送到有活力的皮肤和/或扩散到毛囊；以及(Iii)在环境触发时，如温度、pH、酶活性或氧化还原电位，以治疗相关的浓度释放它们。关于纳米凝胶性质对药物载量的影响、它们的皮肤输送能力、粘附性/穿透性以及作用方式的基本问题将被解决。

This project deals with the development of water-soluble/dispersible stimuli-responsive nanosized soft particles, so-called "nanogels", that should be able to: (i) encapsulate dexamethasone, tacrolimus, tofacitinib, and etanercept; (ii) transport them into the viable skin and/or diffuse into the hair follicles; and (iii) release them in a therapeutically relevant concentration upon an environmental trigger, such as temperature, pH, enzyme activity, or redox potential. Fundamental questions will be addressed regarding the effect of the nanogel properties with respect to drug loading, their dermal delivery capability, mucoadhesive/-penetrating properties, and the mode of action.