EPR spectroscopic investigations on drug delivery and release of nanocarriers into excised skin and 3D-skin models (B01)

EPR的使用得到进一步发展和使用，以便在纳米载体和微环境中定位药物和药物类似物。同时探测药物和载体，通过连续波和脉冲epr方法研究其应用于皮肤、3d皮肤模型和粘膜后的结构变化。因此，研究了纳米载体的药物释放及其皮肤渗透效率，并将扩展到进一步的药物分析，如依那西普和托法替尼，在不同的纳米载体中，如纳米晶体、pH和氧化还原反应性聚合物结构、沉积肽和热反应性纳米凝胶。

The use of EPR is further developed and used in order to localize the drugs and drug analogs within nanocarriers as well as the microenvironment. Drug and carrier are probed simultaneously, so that their structural changes upon application onto skin, 3D-skin models, and mucosa will be studied by continuous wave- and pulsed-EPR methods. Thereby, the release of drugs from nanocarriers and their skin penetration efficiency is investigated and will be extended to the analysis of further drugs, such as etanercept and tofacitinib, within different nanocarriers, such as nanocrystals, pH and redox responsive polymer architectures, depsipeptides, and thermoresponsive nanogels.