SBIR Phase I: Formulation parameters for delivery of fatty acids to repel biting insects

这个小企业创新研究（SBIR）项目的更广泛的影响/商业潜力是改善个人使用的驱虫剂，影响莱姆病和寨卡等疾病的传播，并对公共卫生产生积极影响。 所提出的创新将通过使用既有效又有吸引力的新型化学物质，在护肤制剂中配制天然驱虫剂，该护肤制剂是全天然的，可安全地直接用于皮肤。该SBIR第一阶段项目建议使用新型天然成分，这些成分被归类为对化妆品安全，与标准合成避蚊胺和目前市售的天然活性物质相比，具有上级驱虫性，并结合脂肪酸用于持续递送机制。该项目将通过以下几个方面来证明一种新的混合解决方案的可行性：1）驱虫功效; 2）安全护肤特性; 3）消费者消费特性。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is to improve personal-use insect repellents, impacting transmission of diseases such as Lyme and Zika, and positively affecting public health. The proposed innovation will formulate a natural insect repellent within a skincare formulation that is all-natural and safe for use directly on skin, by using a novel chemistry that is both effective and attractive to use. This SBIR Phase I project proposes to use novel, natural ingredients classified as safe for cosmetics and offering superior insect repellency, compared to both the standard synthetic DEET and currently marketed natural actives, incorporating fatty acids for a sustained delivery mechanism. This project will demonstrate feasibility of a new hybrid solution by demonstrating: 1) Efficacy for insect repellency; 2) Safety skin care profile; and 3) Consumer consumption properties.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.