CAREER: SusChEM: Copper-Catalyzed Aerobic Dehydrogenative C-C Bond Formation through sp3 C-H Bond Functionalization

该项目由美国国家科学基金会化学合成计划资助，支持印第安纳大学-普渡大学印第安纳波利斯分校（IUPUI）化学与化学生物系葛海波教授的研究。葛教授的研究涉及环保和原子效率的方法来制备重要的有机分子。本研究的成功开展对有机合成化学、医药化学和农业化学等领域产生了重大影响。培养本科生和研究生进入劳动力市场也是这个项目的关键部分。开设了一门新的本科实验课程和一门新的本科实验课程。这些课程着重于过渡金属催化化学和杂环化学在课程中的整合。夏季本科研究项目提高了IUPUI化学和生物化学学生的保留率和参与度，并促进了他们进入就业市场或研究生/专业学校。Ge教授正在开发利用铜催化反应在氧气气氛下将sp3杂化碳氢键转化为碳碳键的方法。这些直接的催化脱氢碳-碳成键反应实现了在各种起始底物中邻杂原子（氮或氧）或亚胺基（碳-氮双键）的sp3碳的选择性氧化。该方法得到扩展，以实现各种杂环化合物的高效合成。这些过程的非对映选择性和对映选择性（使用手性催化剂）也在研究中。

This project, funded by the NSF Chemical Synthesis Program, supports the research of Professor Haibo Ge of the Department of Chemistry and Chemical Biology at Indiana University-Purdue University Indianapolis (IUPUI). Professor Ge's research involves environmentally-friendly and atom-efficient methods for preparing important organic molecules. The successful development of this research has an impact on the fields of synthetic organic, medicinal, and agricultural chemistries. The training of undergraduate and graduate students for entry into the workforce is also a key part of this project. A new course and a new undergraduate laboratory experiment are being developed. These courses focus on the integration of transition-metal-catalyzed and heterocyclic chemistry in the curriculum. The summer undergraduate research program improves retention and engagement among chemistry and biochemistry students at IUPUI, and facilitates their entry into the job market or graduate/professional school.Professor Ge is developing methods for the conversion of sp3-hybridized carbon-hydrogen bonds into carbon-carbon bonds using copper-catalyzed reactions conducted under an atmosphere of oxygen. These direct, catalytic dehydrogenative carbon-carbon bond-forming reactions achieve the selective oxidation of sp3 carbons adjacent to a heteroatom (nitrogen or oxygen) or an imino group (carbon-nitrogen double bond) in a variety of starting substrates. The processes are extended to achieve efficient syntheses of a variety of heterocyclic compounds. The diastereoselective and enantioselective (using chiral catalysts) variants of these processes are also being studied.