STTR Phase I: A Multimodal Integrated System For Improved Cardiopulmonary Resuscitation

SBIR第一阶段项目旨在改善心脏骤停患者的预后。每年约有650，000例心脏骤停，是美国死亡率和发病率的首要原因，估计每年的院外费用为330亿美元。总生存率通常低于10%，患者通常会留下严重的神经损伤。人工心肺复苏术（CPR）仍然是最有效的治疗方法之一，其结果优于现有技术。本项目将开发一种新型医疗设备，提供一种新型的上级自动CPR治疗系统。它结合了多种机械胸部按压方法，以改善复苏过程中患者的血流。该项目将推进临床前研究，以开发第一个临床有效的无创自动CPR设备。该系统集成了用于递送机械CPR的多模式方法，并且因此代表了对仅递送单一模式的CPR的当前系统的显著进步。自动化和可编程的原型将确定方法和时间的最佳组合，以控制多个泵机制，用于应用机械胸外按压，以改善患者的预后。该I期项目将在猪心脏骤停模型中进行优化研究，并开发概念验证模型。这些结果将为适合人类使用的下一代系统提供基础，以及在心肺复苏术期间泵机制和心脏电生理学的血液动力学相互作用的先进研究结果。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。

This SBIR Phase I project aims to improve the outcomes of patients suffering sudden cardiac arrest. Approximately 650,000 cardiac arrests occur each year, representing the top reason for mortality and morbidity in the US and an estimated $33 billion a year for out-of-hospital costs. Overall survival remains generally below 10%, and patients are often left with significant neurological injury. Manual cardiopulmonary resuscitation (CPR) still remains one of the most effective treatments, resulting in better outcomes than current technologies. This project will develop a novel medical device that provides a novel superior automated CPR therapeutic system. It combines multiple methods of mechanical chest compression to improve patient blood flow during resuscitation.This project will advance preclinical research for developing the first clinically effective noninvasive automated CPR device. The system integrates a multimodal approach for delivering mechanical CPR, and therefore represents a significant advancement to current systems that only deliver a single mode of CPR. The automated and programmable prototype will determine the optimal combination of methods and timing, to control multiple pump mechanisms for applying mechanical chest compressions to improve patient outcomes. This Phase I project will conduct optimization studies in a swine model of cardiac arrest and develop a proof-of-concept model. These results will provide the foundation for the next generation system suitable for human use, as well as advance research results on the hemodynamic interactions of pump mechanisms and cardiac electrophysiology during CPR.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.