SBIR Phase I: Motion artifact management for accurate and continuous non-invasive blood pressure monitoring

这个小型企业创新研究（SBIR）第一阶段项目的更广泛的影响/商业潜力是实现准确，连续和广泛可用的血压（BP）测量。目前的标准治疗是使用臂袖装置进行单点时间BP监测。这种方法有两个基本缺点：不准确和无法连续测量血压超过24小时，限制了临床洞察力。连续可靠的BP测量的主要挑战是由于运动（例如手臂姿势）引起的运动伪影。 该项目将推进一种新型设备的开发，用于在无袖带的手腕可穿戴设备中进行无创逐搏BP测量。 在家中和其他环境中准确的24小时血压测量将显著改善全球15亿患有慢性高血压或高血压的人的结果，这是中风和心脏病发作的主要原因。受益于准确的24小时血压测量的其他慢性疾病包括睡眠呼吸暂停、心脏和肾衰竭以及痴呆症。该小型企业创新研究（SBIR）I期项目利用高灵敏度的光机械传感器捕获桡动脉上皮肤位移的视频图像，以连续独立测量收缩压和舒张压。该技术在静止条件下准确且连续地测量BP（即，坐着或躺着）。该项目的目标是识别、表征和解决医院重症监护室和手术室日常使用过程中出现的运动伪影。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to enable accurate, continuous, and widely available blood pressure (BP) measurements. The current standard of care is single point-in-time BP monitoring using an arm-cuff device. This method has two basic drawbacks: inaccuracy and the inability to measure BP continuously over 24 hours, limiting clinical insight. The major challenge to continuous reliable BP measurements is motion artifacts due to movement, such as an arm gestures. This project will advance development of a novel device for non-invasive beat-to-beat BP measurement in a cuff-less, wrist-wearable device. Accurate 24-hour BP measurement at home and other settings will significantly improve outcomes for 1.5 billion people globally who suffer from chronic high BP or hypertension, a leading cause of stroke and heart attacks. Other chronic conditions benefiting from accurate 24-hour BP measurement include sleep apnea, heart and renal failure, and dementia. This Small Business Innovation Research (SBIR) Phase I project utilizes a highly sensitive optomechanical sensor to capture video images of skin displacement over the radial artery to independently measure systolic and diastolic BP continuously. The technology measures BP accurately and continuously in stationary conditions (i.e., seated or lying down). The goal of this project is to identify, characterize and address motion artifacts that occur during routine use in hospital intensive care units and operating rooms.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.