Mechanistic Organic Photochemistry: Dark Processes and Toxicity Priming

在化学系化学结构、动力学和机理b （CSDM-B）项目的支持下，纽约城市大学布鲁克林学院的Alexander Greer教授正在分析涉及氧气的光化学反应及其下游反应中出现的后续过程。这些研究主要集中在二级、三级和四级氧化过程的反卷积。这项工作涉及合成化学、物理有机化学和光化学的主题。这些研究还寻求改善细菌消毒的控制，加深对有机自由基和氧化化学的理解，以及基于使用新型人造表面的材料氧化。该项目通过提供对环境微粒、材料老化和水消毒的深入了解，对社会具有潜在的广泛影响。该项目将支持研究生、本科生和高中生在摄影科学方面进行培训，并提供专业发展。此外，Greer教授将培养STEM（科学、技术、工程和数学）人才，通过开发美国光生物学协会的教育工作者和学生在线资源项目，吸引更多的人参与到光科学领域。有了这个奖项，Greer研究小组将使用光敏氧化反应的相分离来分类形成的特定活性氧中间体。通过使用双相和三相反应，顺序光照和后光照过程的步骤有望在机械上实现。该研究旨在通过四元反应机制解决连续光照和后光照过程，并确定特定的初级产物。这项工作将揭示下游光化学反应，以反卷积两阶段光暗（L-D）和四阶段L-D-L-D事件，从而深入了解多阶段氧化事件。在这些过程中形成的活性氧中间体可以被合理地操纵和调整其反应性，这与许多主题有关。该研究与天然和合成分子的选择性氧化有关，对指导氧化抗微生物靶向工作具有更广泛的意义，同时最大限度地减少对非靶点和材料的损害。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With support from the Chemical Structure, Dynamics and Mechanisms-B (CSDM-B) Program of the Chemistry Division, Professor Alexander Greer at the City University of New York, Brooklyn College is analyzing photochemical reactions involving oxygen gas and subsequent processes that arise in their downstream reactions. These studies focus on deconvoluting primary from secondary, tertiary, and quaternary photo-oxidation processes. The work is relevant to topics in synthetic chemistry, physical organic chemistry, and photochemistry. These studies also seek to improve the control of bacterial disinfection, and deepen understanding of organic radical and oxidation chemistry, as well as materials oxidation based on the use of novel artificial surfaces. The project has potential broad impacts to society by providing insight into environmental particulates, materials aging, and water disinfection. The project will support graduate, undergraduate, and high school students to train them in the photo-sciences and provide professional development. Furthermore, Professor Greer will cultivate STEM (science, technology, engineering and mathematics) talent to engage a wider audience in the photo-sciences by developing the American Society of Photobiology’s program of Online Resources for Educators & Students.With this award, the Greer research group will use phase separation of photosensitized oxidation reactions to sort out particular reactive oxygen intermediates that are formed. Steps in sequential light and post-illumination processes are expected to become mechanistically accessible through the use of bi- and triphasic reactions. The research aims to resolve sequential light and post-illumination processes and determine specific primary through quaternary reaction mechanisms. The work will uncover downstream photochemical reactions to deconvolute two-stage light-dark (L-D) and four-stage L-D-L-D events to gain insight into multi-stage oxidative events. The reactive oxygen intermediates formed in these events may be rationally manipulated and their reactivity tuned, which is relevant to many topics. The research is relevant to selective oxidation of natural and synthetic molecules with broader implications for guiding efforts in oxidative anti-microbial targeting, while minimizing damage to non-target sites and materials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.