Regulation of cell signaling by inner leaflets (18)

叶内脂类如何在受体及其下游信号效应蛋白水平上直接调节EGF受体信号转导？为了了解这一现象，我们将应用细胞、生化和质谱学方法将受体信号与脂质变构反馈机制联系起来。同时，我们将使用合成膜系统和笼状脂类来揭示共同分享的信号效应蛋白被控制地募集到膜上的分子基础。

How can inner leaflet lipids directly regulate EGF receptor signaling at the level of the receptor and its downstream signaling effector proteins? Aiming at understanding this phenomenon, we will apply cellular, biochemical and mass spectrometry methods to correlate receptor signaling with lipid allosteric feedback mechanisms. In parallel, we will use synthetic membrane systems and caged lipids to reveal the molecular basis for the controlled recruitment of commonly shared signaling effector proteins to the membrane.