SBIR Phase I: Sustainable antioxidants for industrial process fluids

这个小企业创新研究（SBIR）第一阶段项目的更广泛的影响/商业潜力是开发用于工业过程的生物基抗氧化剂产品。肽抗氧化剂的商业开发在消费者、食品或治疗应用中受到限制。该项目将开发来自农业生物质酶消化的肽抗氧化剂，作为工业流体加工和储存中使用的合成抗氧化剂的替代品。虽然合成抗氧化剂对于许多工业过程的稳定至关重要，但它们来自石油，往往具有毒性和/或环境安全问题。由此产生的产品将是一流的创新产品，比现有产品更安全，更环保。项目活动将验证肽在初始目标应用领域的性能：乙烯基单体流体和工艺的稳定性。这项研究最初将集中在乙烯基单体加工以及其他四个可持续抗氧化剂可能产生重大影响的工业市场。预计到2022年，这五个市场的合成抗氧化剂消费量将接近100万吨。SBIR第一阶段项目旨在开发一种源自可持续材料的生物基抗氧化剂产品，适用于工业过程流体。来源于植物蛋白酶消化的抗氧化肽具有在工业过程中替代合成抗氧化剂的潜力。该项目的重点是工艺兼容性，产品稳定性和抗氧化性能作为关键技术障碍。该项目将创建一个由植物蛋白酶消化产生的抗氧化肽库。然后将在工艺条件下测试该文库中肽与代表性流体的溶解度、潜在制剂设计以及所设计制剂的热稳定性和储存稳定性。该项目将降低技术壁垒，推动肽类抗氧化剂在许多行业的应用商业化发展。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to develop bio-based antioxidant products for industrial processes. Commercial development of peptide antioxidants has been limited for use in consumer, food, or therapeutic applications. This project will develop peptide antioxidants derived from the enzymatic digestion of agricultural biomass as alternatives to synthetic antioxidants used in the processing and storage of industrial fluids. Although synthetic antioxidants are critical for the stabilization of many industrial processes, they are derived from petroleum and tend to have toxicity and/or environmental safety concerns. The products resulting from this effort will be first-in-class innovations; safer and more environmentally responsible than existing products. Project activities will validate peptide performance in the initial target application area: the stabilization of vinyl monomer fluids and processes. This research will initially focus on vinyl monomer processing as well as four additional industrial markets where sustainable antioxidants could have a high impact. The estimated consumption of synthetic antioxidants in the five combined markets in 2022 will be close to 1 million tons.This SBIR Phase I project seeks to develop a bio-based antioxidant product derived from sustainable materials and suitable for industrial process fluids. Antioxidant peptides derived from the enzymatic digestion of plant-based proteins have the potential to replace synthetic antioxidants in industrial processes. This project focuses on process compatibility, product stability, and antioxidative performance as key technical hurdles. This project will create a library of antioxidative peptides generated by the enzymatic digestion of plant proteins. This library will then be tested for the solubility of peptides with representative fluids under process conditions, potential formulation design, and for thermal and storage stability of the designed formulations. This project will lower technical barriers to advancing the commercial development of peptide antioxidants for applications across many industries.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.