Conference: Emerging Statistical and Quantitative Issues in Genomic Research in Health Sciences

2023年定量基因组学（PQG）项目会议，题为“遗传学和基因组学多样性”，将于2023年10月17日至18日在哈佛医学院约瑟夫·b·马丁会议中心举行。这个长期存在的哈佛t.h. Chan学院公共卫生计划在定量基因组学会议系列集中于及时的跨学科讨论在遗传和基因组科学中新兴的统计和计算挑战。每次会议的焦点都与科学前沿同步发展。该系列的一个关键特点是其跨学科性质，定量和主题科学家共同讨论在人类疾病的尖端遗传和基因组研究中出现的统计和定量问题。与会者批评现有的定量方法，讨论新出现的统计和定量问题，确定未来研究的优先事项，并传播结果。遗传和基因组学的多样性越来越受到人们的欢迎，这不仅是为了进行更有力的研究，也是因为需要避免医疗保健系统中结构性不平等的进一步加剧，并为改善这种不平等制定一条前进的道路。近年来，遗传学和基因组学在提高研究参与者和劳动力多样性方面做出了重大努力，包括在发现和功能研究中纳入不同的群体，以及为公平的临床影响授权或铺平道路的转化努力。2023年的会议将为跨学科研究人员提供一个平台，就增加遗传和基因组研究多样性的定量挑战和机遇进行深入讨论。我们将认真招收包括研究生、博士后在内的初级研究人员，特别是少数民族和女性作为演讲者和参与者。2023年会议主题的推动力来自解决遗传和基因组研究多样性的统计和定量问题的迫切需要。会议的三个主题包括：(1)基因定位和变异功能研究的多样性；(2)翻译遗传学多样性：多基因风险与临床实施；(3)我们如何在承认过去的同时继续前进？第一个主题的例子包括多祖先遗传关联测试、精细定位和eQTL分析。第二个主题的例子包括跨种族多基因风险预测和迁移学习。第三个主题的例子包括提高在基因组学研究中使用种群描述符的透明度和建立全球合作遗传研究框架。会议上讨论的教育和研究活动将为促进遗传和基因组研究的多样性做出重要贡献，并将有助于创造确保和维持美国经济和技术竞争力所需的科学基础和劳动力，延长和拯救生命，促进国家安全。欲了解更多信息，请参阅www.hsph.harvard.edu/pqg-conference/.This该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The 2023 Conference of the Program in Quantitative Genomics (PQG), entitled “Diversity in Genetics and Genomics” will take place at the Joseph B. Martin Conference Center at the Harvard Medical School on October 17-18, 2023. This long-standing Harvard T. H. Chan School Public Health Program in Quantitative Genomics Conference series focuses on timely interdisciplinary discussions on emerging statistical and computational challenges in genetic and genomic science. The focus of each conference evolves in parallel to scientific frontiers. A key feature of the series is its interdisciplinary nature, where quantitative and subject-matter scientists jointly discuss statistical and quantitative issues that arise in cutting-edge genetic and genomic research in human diseases. Conference participants critique existing quantitative methods, discuss emerging statistical and quantitative issues, identify priorities for future research, and disseminate results. Diversity in genetic and genomics has been increasingly embraced not only for enabling more powerful studies but also because of the need to avoid further exacerbation of structured inequalities in healthcare systems and to chart a path forward for their amelioration. Significant effort has been made in recent years to improve study participant and workforce diversity in genetics and genomics, including the inclusion of diverse groups in discovery and functional studies and translational efforts to empower or pave the road for equitable clinical impact. The 2023 conference will provide a platform to engage inter-disciplinary researchers to have in-depth discussions on the quantitative challenges and opportunities in increasing diversity in genetic and genomic research. We will make serious efforts to recruit junior researchers, including graduate students, postdoctoral fellows, in particular underrepresented minorities and women, as speakers and participants. The impetus for the 2023 conference theme comes from the pressing need to address the statistical and quantitative issues in diversity in genetic and genomic research. The three topics of the conference include (1) Diversity for gene mapping and studying variant functions; (2) Diversity for translational genetics: polygenic risk and clinical implementation; (3) How do we move forward while acknowledging the past? Examples of the first topic include multi-ancestry genetic association tests, fine-mapping, and eQTL analysis. Examples of the second topic include trans-ethnic polygenic risk prediction and transferred learning. Examples of the third topic include enhancing transparency in the use of population descriptors in genomics research and building global collaborative genetic research frameworks. The education and research activities discussed at the conference will make important contributions to advance efforts on increasing diversity of genetic and genomic research, and will help create the scientific basis and workforce required to ensure and sustain US competitiveness both economically and technologically, prolonging and saving lives, and promoting national security. For more information, see www.hsph.harvard.edu/pqg-conference/.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.