Structure, function and regulation of toxin-induced microtubule-based cell protrusions (C01)

越来越多的疾病归因于纤毛功能障碍(纤毛病变)，纤毛是基于微管(MT)的细胞突起。肌动蛋白解聚毒素(如艰难梭菌毒素CDT)诱导膜突起，这将被用作纤毛模型。该项目的主要目标是：a)研究隔素在基于MT的细胞突起的形成和功能中的作用和调节；b)分析它们的内容；c)表征纤毛样结构的交通和信号。这些研究将为基于MT的细胞室的形成、结构和功能提供新的见解，并更好地理解纤毛疾病。

A growing number of diseases are attributed to dysfunction of cilia (ciliopathies), which are microtubule (MT)-based cell protrusions. Actin-depolymerizing toxins (e.g. C. difficile toxin CDT) induce membrane protrusions, which will be used as a cilia model. The main goals of the project are a) the examination of the role and regulation of septins in formation and function of the MT-based cell protrusions, b) analysis of their content and c) characterization of traffick and signaling of the cilia-like structures. The investigations will offer new insights into formation, structure and function of the MT-based cell compartments and to a better understanding of ciliopathies.