Enhancement of HIV Env specific antibody responses by intrastructural help from heterologous T helper cells (21)

通过结构内帮助机制，Gag特异性t辅助细胞通过含有Gag和Env的病毒样颗粒（VLPs）加强免疫后，增加小鼠的Env抗体应答。当前项目的目的是利用这种基础结构帮助调节异源T辅助细胞对HIV Env的抗体反应。小鼠先对异源抗原免疫，再用含有异源抗原的VLPs加强免疫。通过对异源抗原的不同启动模式，我们的目标是调节对HIV Env的体液免疫反应，特别关注诱导粘膜免疫反应

Gag-specific T-helper cells increase the Env antibody response in mice after booster immun-izations with virus-like particles (VLPs) containing Gag and Env by the intrastructural help mechanism. The aim of the current project is to exploit this intrastructural help to modulate the antibody response to HIV Env by heterologous T helper cells. Mice will be immunized against heterologous antigens prior to booster immunizations with VLPs containing the heterologous antigens inside. By using different modes of priming against the heterologous antigens, we aim to modulate the humoral immune response to the HIV Env with a particular focus on inducing mucosal immune responses