Role of the endocannabinoid system in airway tone regulation under physiological and pathophysiological conditions

内源性大麻素是各种器官内稳态的调节剂。虽然内源性大麻素在神经系统中的功能在过去已被深入研究，但它们在肺中的作用尚不明确。在目前的项目中，我们将研究内源性大麻素系统在生理气道张力调节中的作用，并确定体内和体外潜在的信号通路。此外，我们将确定内源性大麻素对不同哮喘模型肺病理生理的影响。因此，我们将区分对气道张力调节和炎症的影响。这些研究应该为健康和疾病中的气道调节提供见解。这可能会为阻塞性肺疾病带来新的治疗选择。

Endocannabinoids are modulators of the homeostasis of various organs. While endocannabinoid function in the nervous system has been intensively investigated in the past, their role in the lung is ill-defined. In the current project we will investigate the role of the endocannabinoid system in physiological airway tone regulation and identify the underlying signalling pathways ex vivo and in vivo. Moreover, we will determine the impact of endocannabinoids on lung pathophysiology in different asthma models. Hereby we will distinguish effects on airway tone regulation and inflammation. These studies should provide insight into airway regulation in health and disease. This could result in novel therapeutic options for obstructive lung disease.