Exploring the symbiotic interface of amoebal host and its nascent photosynthetic organelle in the amoeba Paulinella chromatophora (Rhizaria, Cercozoa) (B09)

我们的团队对细胞内细菌进化成遗传整合细胞器很感兴趣。在这个项目中，我们将重点关注在这个整合过程中包围进化细胞器的包膜膜的作用。为此，我们开发了一个独特的模型系统：含有蓝藻起源的新生光合细胞器的阿米巴Paulinella chroophora，称为色素团。我们的主要目的是确定使蛋白质在包裹染色质的双包膜上易位的分子机制，并表征该膜系统的超结构和脂质组成。

Our group is interested in the evolution of intracellular bacteria into genetically integrated cell organelles. In this project we will focus on the role of the envelope membranes that surround the evolving organelle during this integration process. For this purpose, we exploit a unique model system: the amoeba Paulinella chromatophora which contains nascent photosynthetic organelles of cyanobacterial origin, termed chromatophores. Our main aims will be to determine the molecular mechanisms that enable protein translocations across the double envelope membrane enclosing the chromatophore and to characterize ultra-structure and lipid composition of this membrane system.