FOR 806: Interfering with Intracellular Protein-protein Interactions - Probing Protein Functions with Small Molecules

细胞通路内的信息流在很大程度上依赖于可逆的和特定的蛋白质-蛋白质相互作用。在许多情况下，它们通常涉及延伸的、相对平坦的蛋白质表面，不易被小分子阻断。因此，通过靶向细胞内蛋白-蛋白相互作用的药理干扰是一项特别艰巨的任务，需要在分子生物学和化学的界面上进行研究。

The assorted flow of information within cellular pathways largely relies on reversible and specific protein-protein interactions. In many instances, they often involve extended, relatively flat protein surfaces, which cannot easily be blocked by small molecules. Therefore, pharmacological interference by targeting intracellular protein-protein interactions is an especially demanding task, requiring research at the interface of molecular biology and chemistry.