Synthetic approaches towards the next generation of photo-controlled antibiotics

这项研究的首要目标是创造出可以通过光线远程控制活性的抗生素。这将有助于对抗环境中活性抗生素的不断积累以及许多细菌菌株中相关的耐药性上升。此外，这种对抗生素活性的控制可以帮助克服抗生素治疗的选择性问题和随之而来的副作用。基于最近通过光开关抗生素通过光控制细菌生长的概念验证，我们计划进一步改进这一概念，并采取下一步措施实现前瞻性临床应用。实现新的和改进的光响应抗生素结构的初始方法已经成功地开发了可光切换的2，4-二氨基嘧啶衍生物。现在的主要目标是修改新开发的系统，以便用可见光而不是紫外线照射来控制活性，这在这一点上仍然是必要的。这将构成这一研究领域的重大突破，并开辟了有趣的新可能性，例如仅用光以可逆方式原位控制细菌生长的前景。

The overarching goal of the research is to create antibiotics whose activity can be remotely controlled by light. This would help to counter the constant build-up of active antibiotics in the environment and the related rise of resistances in many bacterial strains. Also, such control over antibiotic activity could help to overcome selectivity problems and consequential side-effects of antibiotic treatments. Based on a recent proof-of-concept for the control of bacterial growth by light through photoswitchable antibiotics, we plan to further improve upon this concept and take the next steps towards prospective clinical applicability. An initial approach to realize new and improved photoresponsive antibiotic structures was already successful with the development of photoswitchable 2,4-diaminopyrimidine derivatives. A primary goal now is to modify the newly developed system in such a way that a control of activity can be achieved with visible light instead of UV irradiation, as is still necessary at this point. This would constitute a major breakthrough in this field of research, and open up intriguing new possibilities, such as the prospect of controlling bacterial growth in situ only with light in a reversible fashion.