SOLAR III: Asthma and allergies from school age up to working life - analyses of occupational exposures and transgenerational effects over three generations.20-years Follow-up of the ISAAC Phase II Study in Germany.

《职业性过敏风险研究》是一项以人群为基础的关于哮喘和过敏症的前瞻性队列研究，重点关注职业性接触的影响。这项研究是在儿童哮喘和过敏症国际研究(ISAC)第二阶段的参与者中进行的，该研究最初在1995/1996年调查了德国慕尼黑和德累斯顿等城市的小学生(9-11岁)。这项基线研究在2002-03年和2007-2009年通过了第一次和第二次后续太阳能I和太阳能II；这一队列的参与者组成了G1代，以继续这里建议的研究。这些参与者从小学开始就对哮喘和过敏的病程进行了纵向评估。他们的父母(G0代)也可以获得有关产前风险因素的信息。自2009年以来，SOLAII参与者的孩子(G2代)被招募到出生队列研究(ACROSSOLAR)中。跟随G1一代的参与者，直到他们生命的第四个十年，以及他们的伴侣(G1)和他们的父母(G0)和孩子(G2)，应描述三代人的哮喘和过敏过程。考虑到表观遗传效应，将特别审查职业和环境暴露的影响。为实现这些目标，应根据本提案进行G1代(30-32岁)的第三次后续行动和G2代(6-11岁)的第一次后续行动。所有2.051名SOLAR II参与者将被邀请完成一份关于工作历史、环境暴露、哮喘和过敏的纸质问卷。此外，还将对125名G2一代的参与者及其父母进行问卷调查，并为他们提供临床检查。过敏测试、肺功能测试和支气管激发测试将在G2代进行，而CD4+T细胞的全基因组甲基化将在G1和G2代进行检查。本次调查的结果将有助于理解特应性疾病在职业暴露下的纵向病程。包括三代人有助于更好地了解表观遗传效应，从而更好地理解特应性疾病的起源。因此，从长远来看，这些研究将有助于这些疾病的预防。

The Study on Occupational Allergy Risks (SOLAR) is a population-based, prospective cohort study on asthma and allergies focussing on the impact of occupational exposures. This study was conducted in the participants of Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC), which in 1995/1996 initially examined elementary school children (9-11 years) in the German cities of Munich and Dresden, among others. This baseline study was succeeded in 2002-03 and 2007-2009 by the 1st and 2nd follow-up SOLAR I und SOLAR II; the participants of this cohort form the G1 generation for the continuation of the study suggested here. The course of asthma and allergies since elementary school was assessed longitudinally in these participants. Information on prenatal risk factors are available for their parents (G0 generation) as well. Since 2009, the children (G2 generation) of the SOLAR II participants are being recruited in a birth cohort study (ACROSSOLAR). Following the participants of the G1 generation until their 4th decade of life, as well as their partners (G1) and their parents (G0) and children (G2), the course of asthma and allergies shall be described across three generations. The influence of occupational as well as environmental exposures will be examined in particular, taking into account epigenetic effects. To achieve these aims, the 3rd follow-up of the G1 generation (aged 30-32 years) and the 1st follow-up of the G2 generation (aged 6-11 years) shall be conducted with the presented proposal. All of the 2.051 SOLAR II participants will be invited to complete a paper questionnaire on work history, environmental exposures and asthma as well as allergies. The 125 participants of the G2 generation and their parents will be surveyed by questionnaire as well; moreover, clinical examinations will be offered to them. Allergy testing, lung function testing and bronchial challenge testing will be performed in the G2 generation, while genome-wide methylation in CD4+ T cells will be examined in the G1 and G2 generations. The results of this investigation will contribute to the comprehension of the longitudinal course of atopic diseases under special consideration of occupational exosures. The inclusion of three generations facilitates a better understanding of epigenetic effects and hence the genesis of atopic diseases. Thus, these studies will be conducive to the prevention of these diseases in the long term.