Localized Gas Phase Transport: Fundamental Research and Applications

这个跨学科的建议是在气溶胶科学和收集和检测空气中的颗粒的横截面。该提案描述了我们发现的一种新的传输机制的研究，该机制支持以比以前更高的速度局部收集空气中的颗粒。简化后的过程是定向电动力学输运过程。据了解，其机制是基于高迁移率气体离子与空气中的粒子、有图案的衬底和载气之间的相互作用。该工艺导致在图案化衬底上的预定感测点上局部收集和集中空气中颗粒。所发现的工艺适用于广泛的颗粒尺寸（到目前为止，颗粒重量为15个数量级，102da至3x1017Da）和类型（有机和无机）。在《自然通讯》上发表的第一篇文章中，我们证明了收集过程比常用的仅扩散传输快几个数量级。尽管人们对这个过程知之甚少，但随后出现了几个直接的应用程序。例如，在一篇名为《空气分析物的局部收集：一种改善现有气体传感器设计响应时间的传输驱动方法》的出版物中，增加的沉积速率被应用于检测空气中的分子。在随后的出版物[3]中，题为>基于有源矩阵的机载分析物收集：提供曝光历史和指纹的分析物记录芯片讨论了分析物记录芯片的想法。在第四个[4]和非常不同的应用中，发现的工艺被用于收集金属纳米颗粒，以高速生长独立的点对点纳米线桥。具体项目的目标是对底层过程和应用进行基础研究。例如，从理论输运方程的观点来看，除非反应动力学（粘着系数）不同，否则观察到的异常高的收集率是无法解释的。所提出的工艺利用带电离子、空气粒子、具有可编程电荷耗散接触点的图案衬底和载气之间的相互作用。建议安装实验平台以获取相关工艺参数（气体离子浓度、粒子数浓度、局部气体流量、离子耗散电流和电位分布）。从应用的角度来看，我们想把重点放在最近发表的想法[3]上，它描述了一种在芯片大小的基板上以有源矩阵类型的方式收集机载分析物的通用方法。最后，我们想扩大分析物颗粒的范围，包括空气病毒生物学领域的空气传播病原体。为了准备这个建议，我们已经用空气传播的噬菌体进行了第一次实验。

This interdisciplinary proposal is at the cross-section of Aerosol science and the collection and detection of Airborne particles. The proposal describes the investigation of a new transport mechanism that we discovered, which supports the localized collection of airborne particles at a higher rate than previously possible. Strongly simplified the process is a directed electrodynamic transport process. The mechanism, as far as it is understood, is based on the interplay between high mobility gas ions with airborne particles, a patterned substrate, and a carrier gas. The process leads to localized collection and concentration of airborne particles at predetermined sensing points on a patterned substrate. The discovered process is applicable to a wide range of particle sizes (15 orders of magnitude so far in terms of particle weight, 102 Da to 3x1017Da) and types (organic and inorganic). In a first publication in Nature communications [1] we demonstrate that the collection process is several orders of magnitudes faster than the commonly used diffusion only transport. Despite the fact that the process is only poorly understood several immediate applications followed. For example in a publication [2] entitled >Localized Collection of Airborne Analytes: A Transport Driven Approach to Improve the Response Time of Existing Gas Sensor Designs< the increased deposition rate was applied to detect airborne molecules. In the subsequent publication [3] entitled >Active Matrix Based Collection of Airborne Analytes: An Analyte Recording Chip Providing Exposure History and Finger Print< the idea of an analyte recording chip is discussed. In a fourth [4] and very different application the discovered process was use to collect metallic nanoparticles to grow freestanding point to point nanowire bridges at high rates. The specific project targets the fundamental study of the underlying process and applications. For example, from a theoretical transport equation point of view the observed abnormally high collection rate cannot be explained unless the reaction kinetics (sticking coefficient) is different. The proposed process utilizes the interplay between charged ions, airborne particles, a pattered substrate with programmable charge dissipating contact points, and a carrier gas. The installation of an experimental platform is proposed to gain access to the relevant process parameter (gas ion concentration, particle number concentration, localized gas flow, ionic dissipation current, and potential profile). From an application point of view we would like to focus on the recently published idea [3] which describes a generic approach to collect airborne analytes in an active matrix type fashion on chip sized substrates. Finally, we would like to extend the range of analyte particles to include Airborne pathogens within the field of aerovirobiology. In preparation for the proposal we have conducted first experiments with airborne Bacteriophages.