Effect of antioxidans on the reduction of DNA toxicity caused by intermediates and eluates from commercially available and experimental dental restorative materials

单体和单体被用作牙齿修复材料。未转化的化合物可以从牙科复合材料中释放出来，并可以进入人体。（co）单体的吸收、分布和排泄已经在动物研究中得到阐明。在这些（co）单体的代谢过程中，检测到有毒中间体如环氧化物的形成。环氧化合物被认为是有毒化合物，它们可以影响细胞中的redoxhomöstasis。由于环氧化物及其连续反应的潜在反应性，在本研究中，抗氧化剂对减少从市售和实验复合材料中洗脱的环氧化物和（co）单体引起的DNA损伤的作用应该在人体细胞中进行检验。本研究应用是一种合作应用。在所有联合研究中，使用相同的牙科材料、相同的细胞和相同的生产工艺，例如从牙科材料中生产洗脱液。

Comonomers and monomers are used as dental restorative materials. Unconverted com-pounds can be released from dental composites and can enter the body in humans. The up-take, distribution, and excretion of (co)monomers have been elucidated in animal studies. In the metabolism of these (co)monomers the formation of toxic intermediates as epoxides were detected. Epoxy-compounds are regarded as toxic compounds and they can influence the redoxhomöstasis in the cells.Due to the potential reactivity of epoxides and their consecutive reactions, in this study the effect of antioxidans on the reduction of DNA damages caused by epoxides and (co)monomers eluted from commercially available and experimental composites should be examined in human cells. This research application represents a cooperation ap-plication. In all joint studies identical dental materials, identical cells and identical manufactur-ing processes for the production of e.g. eluates from dental materials are used.