Noninvasive electrocardiographic imaging of activation sequence and substrate for ventricular tachycardia

室性心律失常是世界范围内心源性猝死的主要原因。室性心动过速（VT）是一种危及生命的心律失常，表现为反复快速的心律，可引发更致命的心室颤动。在临床常规中，标准的12导联心电图用于心律失常的诊断。然而，它只提供了关于心脏状况的全局信息，并依赖于心脏病专家的经验，而没有考虑到患者的具体细节。心电图成像是一项不断发展的技术，允许从体表电位图（BSPMs）无创重建心脏来源。在本研究项目中，心电成像将用于重建室性心动过速的激活序列。为此，将收集单形态室速患者的数据，包括MRI、电解剖测图和BSPMs。无创重建的质量将根据心内信号进行评估。心肌梗死的疤痕将用DE-MRI成像。通过这种方式，将以VT为重点评估反问题的解决方案。此外，ECG成像将与心脏MRI相结合，以描述基底修改，并创建具有ECG成像患者特异性基底特性的模型。本研究将评估ECGI在改善室速患者风险分层和个性化治疗计划方面的临床潜力。

Ventricular arrhythmias are a major cause of sudden cardiac death worldwide. Ventricular tachycardia (VT) is a life-threatening arrhythmia that expresses in repetitive fast heart rhythm and can trigger even more lethal ventricular fibrillation. In clinical routine, a standard 12-lead ECG is employed for diagnosis of cardiac arrhythmias. However, it provides only global information on the heart condition and rests on cardiologists experience without taking into account patient-specific details. ECG imaging is an evolving technology allowing for noninvasive reconstruction of cardiac sources from body surface potential maps (BSPMs). In this research project, ECG imaging will be applied to reconstruct the activation sequence of ventricular tachycardias. To this end, data of patients with monomorphic VT will be collected, including MRI, electroanatomical mapping measurements and BSPMs. The quality of noninvasive reconstructions will then be evaluated against the intracardiac signals. Scars due to myocardial infarction will be imaged with DE-MRI. This way, the inverse problem solution will be evaluated with a focus on VT. Furthermore, ECG imaging will be combined with cardiac MRI to depict substrate modifications and to create models with patient-specific substrate properties for ECG imaging. This study will evaluate the clinical potential of ECGI for an improved risk stratification and personalized treatment planning for VT patients.