Development of novel transfection system using DNA gel

在最近的研究中，自组装DNA结构与由聚合物组成的液-液相分离系统之间的相互作用被研究。据观察，DNA结构可以被这些隔室选择性地吸收，导致模仿人工细胞的自组装以及核酸和细胞器的相互作用。基于这些发现，我开发了一种纯化自组装DNA结构的方法，并基于DNA折纸在液滴界面的积累创建了一类新的胶体体。这使得能够创建可以自组织成细胞样结构的胶体体。在未来，我将探索通过DNA coloidosomes的膜易位核酸的可能性，这可能会发现在DNA测序技术和合成细胞模型上的核酸运输thourgh膜的应用。

In recent research, the interaction between self-assembled DNA structures and liquid-liquid phase-separated systems composed of polymers was investigated. It was observed that DNA structures can be selectively taken up by these compartments, leading to self-assembly that mimics artificial cells and the interaction of nucleic acids and organelles. Based on these findings, I developed a method for purifying self-assembled DNA structures and created a new category of colloidossomes based on the accumulation of DNA origami at the interface of droplets. This enabled the creation of colloidosomes that can self-organise into cellular like structures. In the future, I will explore the possibility of translocating nucleic through membranes of DNA coloidosomes, which might find application in DNA sequencing technology and on synthetic cell models for the transport of nucleic acids thourgh membranes.